ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025
Zinc-mediated changes to cytosol osmolyte and lipid profiles in soil fungi under growth-stimulating conditions.
Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Heavy metals (HM) exhibit a dual effect on fungal growth and development, displaying both toxicity and stimulatory properties. At low concentrations, HM can enhance fungal biomass, colony growth, sporulation, nucleic acid synthesis, gene expression, and toxin production. Given that membrane lipids and cytosolic biomolecules (storage lipids, carbohydrates, and polyols) serve as crucial indicators of fungal vitality under both optimal and stress conditions, we hypothesized that growth-stimulating HM exposure would alter their composition, revealing stress responses. Specifically, this study investigated the impact of growth-stimulating zinc concentrations (resulting in a 50-60% increase in biomass) on the membrane and storage lipid profiles, as well as the cytosolic osmolyte profiles, of the soil filamentous fungi Clonostachys farinosa, Fusarium equiseti, Trichoderma asperellum, and Trichoderma harzianum. All fungi exhibited a hormetic response to zinc, evidenced by increased biomass and stimulated sporulation. Zinc altered the composition of both membrane lipids and intracellular biomolecules. Specifically, we observed a consistent decrease in membrane sterol content, an increase in the unsaturation of membrane phospholipid fatty acids, and a reduction in storage triacylglycerides across all species. Mannitol dominated the carbohydrate and polyol profiles, and its proportion increased in the presence of zinc ions, while trehalose levels remained unchanged or decreased. These collective findings suggest a predominantly hormetic, rather than a stress-induced, response to zinc exposure.
Indexed as
Identifiers
41166048What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.