Evidence map›Paper›PMID 41166037›Full record

ArticleGeroScience2026

Age differences in spontaneous cerebrovascular reactivity at rest.

Allison C Engstrom, Shubir Dutt, John Paul M Alitin, Arunima Kapoor, Trevor Lohman, Isabel J Sible, Anisa J Marshall, Fatemah Shenasa, Jillian L Joyce, Aimée Gaubert and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Allison C EngstromDepartment of Psychological Science, Social and Behavioral Sciences Gateway, University of California, Irvine, 4201, Irvine, CA, 92697-7085, USA.
Shubir DuttMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4Th St Suite 212, San Francisco, CA, 94158, USA.
John Paul M AlitinLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Arunima KapoorDepartment of Psychological Science, Social and Behavioral Sciences Gateway, University of California, Irvine, 4201, Irvine, CA, 92697-7085, USA.
Trevor LohmanMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4Th St Suite 212, San Francisco, CA, 94158, USA.
Isabel J SibleDepartment of Psychology, G. Mudd Building, University of Southern California, 3620 McClintock Ave, Los Angeles, CA, 90089, USA.
Anisa J MarshallDepartment of Psychology, G. Mudd Building, University of Southern California, 3620 McClintock Ave, Los Angeles, CA, 90089, USA.
Fatemah ShenasaDepartment of Psychological Science, Social and Behavioral Sciences Gateway, University of California, Irvine, 4201, Irvine, CA, 92697-7085, USA.
Jillian L JoyceLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Aimée GaubertLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Farrah FerrerLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Amy NguyenLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA.
Xingfeng ShaoStevens Neuroimaging and Informatics Institute, University of Southern California, 2025 Zonal Ave, Los Angeles, CA, 90033, USA.
Danny J J WangStevens Neuroimaging and Informatics Institute, University of Southern California, 2025 Zonal Ave, Los Angeles, CA, 90033, USA.
Daniel A NationLeonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, USA. danation@usc.edu.ORCID http://orcid.org/0000-0002-9123-0658

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2016 to 2026
$28.4M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
CIHR DFD-170763NIA NIH HHS P01 AG052350NIA NIH HHS P01AG052350NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30AG066530NIA NIH HHS R01 AG060049NIA NIH HHS R01AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R01AG064228NIA NIH HHS R01 AG082073NIA NIH HHS R01AG082073NIH HHS P01AG052350NIH HHS P30AG066530NIH HHS R01AG060049NIH HHS R01AG064228NIH HHS R01AG082073
6 · The paper itself

Abstract

Deficits in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) may indicate vulnerability to vascular dysfunction and cognitive impairment. Prior findings on age-related change in CVR are mixed, and no studies to date have investigated age group differences in spontaneous CVR (sCVR) at rest. The present study compared whole brain and regional sCVR at rest between 24 healthy younger adults (ages 18-34) and 163 cognitively unimpaired older adults (ages 55-87). Relative to younger adults, older adults had deficits in both whole brain and regional sCVR at rest. Among the regions examined, medial temporal lobe areas showed the largest age differences in sCVR at rest. Age differences in sCVR and CBF variability were larger than age differences in mean CBF. Results show age-related deficits in sCVR are present even in cognitively unimpaired older adults, suggesting sCVR may be indicative of cerebrovascular aging. Further research should investigate sCVR as a means for early detection of age-related vascular dysfunction that may predate irreversible vascular brain injury.

Indexed as

AgingBrainCerebrovascular CirculationRestAdolescentAdultAgedAged, 80 and overAge FactorsFemaleHumansMaleMiddle AgedYoung AdultAgingCerebral blood flowCerebrovascular reactivityOlder adults

Identifiers

PMID41166037
PMCPMC13575053

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.