Evidence map›Paper›PMID 41166014›Full record

ArticleJournal of neuro-oncology2025

Radiologic characterization and clinical management of multinodular and vacuolating neuronal tumor (MVNT): a retrospective institutional cohort study.

Austin Carmichael, Umar Arshad, Daniel Martinez Heinemann, Sai Chandan Reddy, Anita Kalluri, Antolin Serrano-Farias, Praneethkumar Madhu, Dhairya A Lakhani, Haris Sair, Karisa C Schreck and 5 more

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Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Austin CarmichaelDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Umar ArshadDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel Martinez HeinemannDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sai Chandan ReddyDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anita KalluriDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Antolin Serrano-FariasDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Praneethkumar MadhuDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dhairya A LakhaniDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Haris SairDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Karisa C SchreckDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Calixto-Hope LucasDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ignacio Gonzalez-GomezDepartment of Pathology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
George I JalloDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jordina Rincon-TorroellaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jrincon2@jhmi.edu.ORCID https://orcid.org/0000-0003-4798-8231

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMultinodular and vacuolating neuronal tumor (MVNT) is a rare, benign entity first recognized by the World Health Organization in 2016. Given that patients with MVNT often present incidentally or with nonspecific symptoms, understanding imaging characteristics and treatment strategies is critical to effective management. This study describes the radiologic characteristics and clinical outcomes of individuals with MVNT through a large retrospective cohort.

methodsA tertiary academic center's radiology database was queried for individuals with "Multinodular and Vacuolating Neuronal Tumors," "MVNT," or "T2-hyperintense nodules." Of 190 patients, 27 were identified with radiologically determined MVNT by two expert neuroradiologists. Clinical, imaging, and management data were collected through retrospective chart review.

resultsThe median age at radiologic discovery of MVNT was 43 years (6-81 years). The most common symptoms at presentation included headaches (11/26, 42.3%) and seizures (7/26, 26.9%). On MRI, MVNTs were often subcortical, nodular lesions that appeared hypointense on T1-weighted imaging (25/27, 92.6%), hyperintense on T2-weighted imaging (27/27, 100%), fluid-attenuated inversion recovery hyperintense (27/27, 100%), and non-contrast enhancing (23/27, 85.2%). Most individuals pursued conservative management with imaging (23/26, 88.5%), though three patients underwent surgery (3/26, 11.5%). Presenting symptoms improved in most conservatively managed (16/23, 69.6%) and both surgical (2/2, 100%) cases by the last follow-up. Neither progression nor recurrence was observed in any case.

conclusionsThis study highlights the nonspecific presentation and characteristic MRI features of MVNT. Our findings support conservative imaging follow-up for most patients with MVNT, though surgery may benefit select patients with severe symptoms, including drug-resistant epilepsy.

Indexed as

Brain NeoplasmsAdolescentAdultAgedAged, 80 and overChildDisease ManagementFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesYoung AdultIncidental findingMultinodular and vacuolating neuronal tumorNeuroradiologySeizures

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PMID41166014

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.