Evidence map›Paper›PMID 41166006›Full record

ArticleNeurochemical research2025

Efficacy of Tranexamic Acid on GABA

Ferda Serdoğan, Kemal Tolga Saraçoğlu, Uğur Aykın, Metehan Akça, Cumaali Demirtaş, Ayten Saraçoğlu, Elif Akova Deniz, Tamer Kuzucuoğlu, Mehmet Yildirim

Abstract read
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In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ferda SerdoğanDepartment of Anesthesiology and Reanimation, Turhal State Hospital, Tokat, Turkey. ferdaserdogan@gmail.com.ORCID http://orcid.org/0000-0002-9515-017X
Kemal Tolga SaraçoğluDepartment of Anesthesiology, University of Florida, Jacksonville, USA.
Uğur AykınDepartment of Physiology, Hamidiye Medical School, University of Health Sciences, Istanbul, Turkey.
Metehan AkçaDepartment of Physiology, Medical School, Tokat Gaziosmanpasa University, Tokat, Turkey.
Cumaali DemirtaşDepartment of Physiology, Hamidiye Medical School, University of Health Sciences, Istanbul, Turkey.
Ayten SaraçoğluDepartment of Anesthesiology, University of Florida, Jacksonville, USA.
Elif Akova DenizDepartment of Anesthesiology and Reanimation, Osmaniye State Hospital, Osmaniye, Turkey.
Tamer KuzucuoğluDepartment of Anesthesiology and Reanimation, Kartal Dr. Lütfi Kırdar City Hospital, University of Health Sciences, Istanbul, Turkey.
Mehmet YildirimDepartment of Physiology, Hamidiye Medical School, University of Health Sciences, Istanbul, Turkey. mehmet.yildirim@sbu.edu.tr.ORCID http://orcid.org/0000-0003-1798-5478

Funding

Scientific Research Projects Coordination Unit of University of Health Sciences SBU-BAP project no: 2020/116
6 · The paper itself

Abstract

Tranexamic acid (TXA) has been associated with an increased risk of postoperative seizures. However, the neuronal mechanisms underlying its proconvulsant effects remain unclear. This study investigated the dose-dependent effects of TXA on neuronal excitability in a penicillin-induced epileptiform activity model and its interaction with GABA

Indexed as

EpilepsyPenicillinsReceptors, GABA-ATranexamic AcidAnimalsDose-Response Relationship, DrugElectrocorticographyMaleRatsRats, Sprague-DawleyPenicillinsReceptors, GABA-ATranexamic AcidExperimental epilepsyGABANeuronal excitabilityTranexamic acid

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.