Evidence map›Paper›PMID 41165962›Full record

ArticleBiological trace element research2026

SLC39A14 is Required for Iron Loading of the Anterior Pituitary of Mice with Genetic Iron Overload.

Joseph Olivera, Shintaro Hoyjo, Toshiyuki Fukada, Mitchell D Knutson

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Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Joseph OliveraFood Science and Human Nutrition Department, University of Florida, Gainesville, 32611, FL, USA.
Shintaro HoyjoDivision of Molecular Psychoneuroimmunology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-Ku, Sapporo, Hokkaido, 060-0815, Japan.
Toshiyuki FukadaMolecular and Cellular Pathology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-boji, Yamashiro-cho, Tokushima, Japan.
Mitchell D KnutsonFood Science and Human Nutrition Department, University of Florida, Gainesville, 32611, FL, USA. mknutson@ufl.edu.ORCID http://orcid.org/0000-0001-9135-4696

Funding

NIH HHS DK080706
6 · The paper itself

Abstract

Patients with iron overload disorders frequently accumulate iron in the pituitary and adrenal glands, leading to endocrine dysfunction. Although this iron loading is well documented, the specific molecular mechanisms of iron accumulation are not well understood. Under normal conditions, most tissues, including pituitary and adrenal gland, acquire iron from circulating transferrin. In iron overload, however, transferrin levels become saturated with iron, resulting in plasma non-transferrin-bound iron (NTBI), which becomes a significant contributor to tissue iron accumulation. Previous studies have shown that the metal-ion transport protein SLC39A14 mediates NTBI uptake in the liver and pancreas. To investigate if SLC39A14 plays a similar role in the pituitary and adrenal glands, we utilized Slc39a14 knockout (Slc39a14

Indexed as

Cation Transport ProteinsIronIron OverloadPituitary Gland, AnteriorAnimalsGPI-Linked ProteinsHemochromatosis ProteinMaleMiceMice, Inbred C57BLMice, KnockoutCation Transport ProteinsGPI-Linked ProteinsHemochromatosis ProteinHJV protein, mouseIronSLC39A14 protein, mouseIron overloadPituitary glandSLC39A14ThalassemiaZIP14

Identifiers

PMID41165962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.