Evidence map›Paper›PMID 41165954›Full record

ArticleInternal and emergency medicine2026

Global, regional, and national burden and trends of liver cancer due to hepatitis B in young adults from 1990 to 2021 and forecast to 2030: insights from the Global Burden of Disease Study 2021.

Jinbo Li, Yaling Li, Bihong Ke, Xiaosheng Zhang, Weigang Wang, Yandi Li, Jia Lian, Tian Yao, Keke Wang, Suping Wang and 1 more

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Article in Internal and emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jinbo LiSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, China.
Yaling LiSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, China.
Bihong KeSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, China.
Xiaosheng ZhangSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, China.
Weigang WangSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, China.
Yandi LiSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, China.
Jia LianSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, China.
Tian YaoFirst Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Keke WangFirst Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Suping WangSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, China. supingwang@sxmu.edu.cn.
Yongliang FengSchool of Public Health, Shanxi Medical University, Taiyuan, 030001, China. yongliang.feng@sxmu.edu.cn.

Funding

Four "Batches" Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province 2023XM037Fundamental Research Program of Shanxi Province 202303021211122National Natural Science Foundation of China 82073622Research Project Supported by Shanxi Scholarship Council of China 2023-096
6 · The paper itself

Abstract

Liver cancer due to hepatitis B (LCHB) presents a major public health challenge, particularly in younger populations. To date, comprehensive analyses of the global burden and changing trends of LCHB in young adults aged 15-49 years are understudied. We collected prevalence, mortality, and disability-adjusted life years (DALYs) between 1990 and 2021 from the Global Burden of Disease (GBD) Study 2021. Percentage change and estimated annual percentage change (EAPC) were calculated to quantify temporal trends. The future burden to 2030 was projected using the Bayesian age-period-cohort (BAPC) model. From 1990 to 2021, the global prevalence, mortality, and DALYs cases of LCHB in young adults increased by 49.72%, 18.70%, and 16.08%, while the age-standardized prevalence rate (ASPR), age-standardized mortality rate (ASMR), and age-standardized DALYs rate (ASDR) declined, with EAPCs of - 0.66%, - 1.49%, and - 1.54%, respectively. The sex ratio remained consistent at 5:1 (male to female). The middle and high-middle SDI regions bore heavier burden than other SDI regions. In 2021, East Asia recorded the highest cases and age-standardized rate of prevalence, mortality, and DALYs. The younger age groups exhibited lower disease burden compared to older ones. New case numbers are predicted to increase globally, particularly in China. While the absolute cases of prevalence, mortality, and DALYs for LCHB in young adults have increased globally, the ASPR, ASMR, and ASDR have declined over the past 32 years. Temporal trend varied by region, country, sex, and age group, with the global burden expected to present ongoing challenges.

Indexed as

Hepatitis BLiver NeoplasmsAdolescentAdultBayes TheoremDisability-Adjusted Life YearsFemaleForecastingGlobal Burden of DiseaseGlobal HealthHumansMaleMiddle AgedPrevalenceYoung AdultBayesian age-period-cohort modelEstimated annual percentage changeGlobal burden of diseaseHepatitis BLiver cancerSocio-demographic index

Identifiers

PMID41165954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.