ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026
Prevalence and risk factors for recurrent Staphylococcus aureus small-colony variants in people with cystic fibrosis followed at the Tuscan Regional Reference Center.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to determine the prevalence of Staphylococcus aureus small colony variants (SCV) in people with cystic fibrosis (pwCF), evaluate the clinical differences of single versus multiple detections of SCVs in respiratory cultures, and assess antibiotic resistance.
methodsThis monocentric retrospective study included pwCF colonised by S. aureus SCVs between January 1, 2017, and December 31, 2023, at the CF centre of Florence, Italy. Clinical data were collected, and patients with single versus recurrent SCV detections were compared to identify risk factors for recurrent SCVs.
resultsAmong 154 pwCF (62 children, 92 adults), SCV was detected in 38.31%. Univariate analysis identified lower percent predicted forced expiratory volume in the first second (ppFEV
conclusionsS. aureus SCVs were highly prevalent in pwCF, although their frequency declined over time with the widespread use of elexacaftor-tezacaftor-ivacaftor. Recurrent SCV detections, but not single episodes, were associated with a progressive decline in respiratory function. Prior TMP-SMX exposure was identified as an independent risk factor for recurrent SCV detections. The clinical implications of these findings require further investigation to clarify causality and guide management strategies.
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