ArticleMikrochimica acta2025
A pH-responsive nanozymes Au@Pt NRs SERS assay platform for the detection of urease enables efficient and accurate differentiation of bacterial and viral pneumonia.
Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Infectious pneumonia represents a significant cause of mortality among intensive care unit (ICU) patients. Clinically, the differentiation between viral and bacterial pneumonia has traditionally relied upon sputum culture methodologies, a process requiring approximately 2-3 days. Leveraging nanozyme technology, we have developed a pH-responsive, indirect urease detection platform based on surface-enhanced Raman spectroscopy (SERS). This platform employs Au@Pt nanorods (Au@Pt NRs) as the core catalytic nanozyme. The principle exploits the specific hydrolysis of urea by urease, which subsequently alters the solution pH. This pH shift modulates the catalytic activity of the nanozyme, thereby influencing the production rate of oxidized 3,3',5,5'-tetramethylbenzidine (ox-TMB). The resultant change in ox-TMB concentration directly impacts the generated SERS signal intensity. The entire assay can be completed within 25 min, demonstrating exceptional rapidity. The platform provides high sensitivity, with a detection limit as low as 10.44 U·L
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