ArticleCellular and molecular life sciences : CMLS2025
Dmrt2 regulates sex-biased neuronal development in the cingulate cortex.
Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Kidney Cyst Epithelia in Tuberous Sclerosis Complex (TSC) Exhibit Propagation and Expansion of A-Intercalated, but Loss of B-Intercalated and Principal Cells: The Role of FOXI1, FOXP1, and DMRT2 Transcription Factors.International journal of molecular sciences · 2026Article
- MicroRNA-181 influences Alzheimer's risk by regulating neprilysin and microtubule-associated tau pathways, offering a novel target.bioRxiv : the preprint server for biology · 2026Article
- A panoramic view of the expression and function of the Doublesex/DMRT gene family inScience advances · 2026Article
- Expression atlas of Dmrt genes across sex and development in the mouse brain: functional insights from the olfactory system.Biology of sex differences · 2026Article
- Evidence That Dmrta2 Acts through Repression ofeNeuro · 2025Article
- Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice.Frontiers in pharmacology · 2025Article
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Authors and funding
5 authors.
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Abstract
Sexual differences are prevalent in the brain. DMRT transcription factors have been postulated as important determinants of sex differences. Previous research focused on the DMA subfamily in the brain. Here, we reveal an unprecedented role for Dmrt2 in regulating the proliferation and development of cortical neurons in mice. Dmrt2 is expressed in deep-layer neurons of the cingulate cortex (CgCx) throughout development. Its downregulation in the CgCx primordium results in premature cell cycle exit of embryonic progenitors and subsequent reduction in cortical plate cellular density at later developmental stages. Dmrt2 expression is higher in male embryos during early development, potentially explaining their increased vulnerability to Dmrt2 depletion. As development progresses, Dmrt2 expression persists in deep-layer neurons, controlling processes like migration, axonal targeting, and neuronal-specific gene expression. This study broadens our understanding of Dmrt2 gene function in the brain and provides insights into the molecular basis of sexual differences in neurodevelopmental processes.
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