Evidence map›Paper›PMID 41165822›Full record

ArticlePlanta2025

SmMYC2 positively regulates the resistance to Botrytis cinerea in Salvia miltiorrhiza.

Lulu Peng, Ying Xu, Yuan Xu, Ruiyan Zhu, Jinyong Cai, Shuiping Zhou, Lili Shao, Tingyao Liu, Minyu Shou, Qinzhe Lin and 6 more

Abstract read
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In one paragraph

Article in Planta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lulu Peng *Laboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Ying Xu *Laboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Yuan XuLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Ruiyan ZhuLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Jinyong CaiNational Key Laboratory of Chinese Medicine Modernization, Pharmacology & Toxicology, Department of Academy, Tasly Pharmaceuticals Co., Ltd, Tianjin, 300410, China.
Shuiping ZhouNational Key Laboratory of Chinese Medicine Modernization, Pharmacology & Toxicology, Department of Academy, Tasly Pharmaceuticals Co., Ltd, Tianjin, 300410, China.
Lili ShaoLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Tingyao LiuLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Minyu ShouLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Qinzhe LinLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Qikai HuangLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Jiaochen QiLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Genbei WangNational Key Laboratory of Chinese Medicine Modernization, Pharmacology & Toxicology, Department of Academy, Tasly Pharmaceuticals Co., Ltd, Tianjin, 300410, China.
Yao WangLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Min ShiLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China. min_shi@zcmu.edu.cn.
Guoyin KaiLaboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, 310053, China. kaiguoyin@zcmu.edu.cn.ORCID http://orcid.org/0000-0001-7586-9067

Funding

National Key Research and Development Program of China 2023YFC3503903National Natural Science Fund of China 82073963National Natural Science Fund of China 82204554The Key Science and Technology Projects of Breeding New Varieties of Agriculture in Zhejiang Province 2021C02074-3The Research Project of Zhejiang Chinese Medical University 2022JKZKTS13The Science Research Fund of Administration of Traditional Chinese Medicine of Zhejiang Province 2023ZR089Zhejiang Provincial Natural Science Foundation of China LQ23H280010
6 · The paper itself

Abstract

MAIN

conclusionThis study unravels the function of SmMYC2 regulating resistance to B. cinerea in S. miltiorrhiza. Salvia miltiorrhiza is a traditional medicinal herb and commonly used to treat cardiovascular and cerebrovascular diseases. Gray mold caused by Botrytis cinerea poses a significant threat to production of many medicinal plants. The key transcription factor SmMYC2 has been found to contribute to promoting the biosynthesis of tanshinones or phenolic acids, and also mediated salt resistance in S. miltiorrhiza. However, limited information underlying its role of resistance to B. cinerea is available. In this study, simultaneous improvement of tanshinone and phenolic acid biosynthesis was observed in transgenic S. miltiorrhiza plants overexpressing SmMYC2 (OE-SmMYC2). Besides, expression pattern analysis revealed that SmMYC2 transcript increased significantly after B. cinerea infection. OE-SmMYC2 plants significantly improved their resistance to B. cinerea, and enhanced the expression level of the defense marker genes, such as SmPR1, SmPR10, SmSam a1, and SmPR-STH2. Besides, three antioxidant enzymes including catalase, peroxidase and superoxide dismutase were increased in OE-SmMYC2 lines, and SmMYC2 reduced the H

Indexed as

BotrytisDisease ResistancePlant DiseasesPlant ProteinsSalvia miltiorrhizaTranscription FactorsAbietanesGene Expression Regulation, PlantHydroxybenzoatesPlants, Genetically ModifiedAbietanesHydroxybenzoatesphenolic acidPlant ProteinstanshinoneTranscription FactorsPhenolic acidResistanceSmMYC2TanshinoneTranscription factorTransgenic plants

Identifiers

PMID41165822

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.