ArticleWorld journal of urology2025
Safety and efficacy of aquablation in men 80 years or older: an analysis of the international collaborative aquablation research urology society (ICARUS) real-world database.
Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Reproducibility of Aquablation outcomes across surgeon experience levels: A descriptive analysis of published studies.BJUI compass · 2026Article
- Aquablation/AquaBeam Waterjet Therapy for Benign Prostatic Hyperplasia: Three-Year Functional and Ejaculatory Outcomes in a Multicenter Real-World Italian Cohort.Lower urinary tract symptoms · 2026Article
- The core aquablation pentafecta: a five-domain composite definition of procedural success and learning curve validation in 300 consecutive cases.Journal of robotic surgery · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAquablation is under-researched, especially in the elderly. As older patients face higher risks of surgical complications, this study aims to evaluate the safety and efficacy of Aquablation in octogenarians.
methodsThis retrospective, multi-center study includes 2136 patients who underwent Aquablation between 2018 and 2024. Patients were divided into two cohorts, ≥ 80 and < 80 years of age, consisting of 206 and 1930 men, respectively. Data included baseline characteristics, operative characteristics, and post-operative functional outcomes. Peri-operative events were compared.
resultsMen ≥ 80 had higher rates of anxiety/depression (32% vs 16%, p = 0.0032), 5α-reductase inhibitor use (35% vs 19%, p = 0.0009), and anticoagulation (56% vs 24%, p < 0.0001). Mean prostate volume was similar between groups, but men ≥ 80 were less likely to have a median lobe (52% vs 63%, p = 0.003). Both groups showed similar improvements in peak urinary flow rate, post-void residual, International Prostate Symptom Score and quality of life. Men ≥ 80 had higher rates of take-back for cystoscopy/clot evacuation (4.4% vs 1.9%, p = 0.034), transfusions (2.9% vs 0.5%, p = 0.003) and 30-day readmissions (4.2% vs 0.7%, p = 0.002). Age and urinary retention were associated with a composite bleeding outcome. There were no changes in erectile function and no differences in retrograde ejaculation between groups.
conclusionThis study is the first to assess Aquablation's safety and efficacy across all ages. Aquablation offers similar voiding improvements in men aged ≥ 80 as in younger men, with slightly higher perioperative risks. Thus, Aquablation should be considered for well-selected, elderly patients with significant BPH who wish to preserve sexual function. However, as fewer than half of patients had follow-up beyond 8 months, these findings primarily reflect short-term outcomes.
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Registered trials
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