Evidence map›Paper›PMID 41165769›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2026

Positive effect of physical activity for depression and major depression: a Mendelian randomization study.

Zhiqiang Du, Lingyi Shi, Qin Zhou, Rongrong Lu, Zhenhe Zhou, Haohao Zhu

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Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhiqiang Du *Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Lingyi Shi *Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Qin ZhouAffiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Rongrong LuAffiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Zhenhe ZhouAffiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Haohao ZhuAffiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China. zhuhh@jiangnan.edu.cn.ORCID http://orcid.org/0000-0003-2352-4854

Funding

National Natural Science Foundation of China 82104244
6 · The paper itself

Abstract

objectiveTo explore the causal relationship between types of physical activity in the last 4 weeks and Depression, Major depression.

methodsWe used summary data from Genome-Wide Association Studies (GWAS) to conduct a Two-Sample Mendelian Randomization (TSMR) analysis. The main method was the Inverse Variance Weighted (IVW) approach, with weighted median, weighted mode, and MR Egger methods as supplements. The evaluation metrics were P-value, OR value, and 95% Confidence Interval (95% CI). Sensitivity analysis was also performed.

resultsGenetically predicted NOPA was significantly associated with an increased risk of Depression. WFP and HDIY were significantly associated with a reduced risk of Depression. LDIY, OE, and SS showed no causal relationship with Depression (P > 0.05). Genetically predicted NOPA was significantly associated with an increased risk of Major depression (NOPA: OR = 15.959, 95% CI: 3.517-72.409, P = 3.98E-03). WFP, HDIY, LDIY, and OE were significantly associated with a reduced risk of Major depression (WFP: OR = 0.235, 95% CI: 0.113-0.487, P = 9.80E-05), (HDIY: OR = 0.419, 95% CI: 0.235-0.748, P = 0.003), (LDIY: OR = 0.467, 95% CI: 0.318-0.685, P = 9.65E-05), (OE: OR = 0.312, 95% CI: 0.145-0.670, P = 0.003). SS showed no causal relationship with Major depression (P > 0.05).

conclusionOur TSMR analysis revealed that types of physical activity in the last 4 weeks, such as WFP and HDIY, may reduce the risk of Depression and Major depression, while NOPA may increase the risk of both. SS had no effect on Depression and Major depression.

Indexed as

DepressionExerciseMajor Depressive DisorderMendelian Randomization AnalysisGenome-Wide Association StudyHumansCausal relationshipDepressionMajor depressionPhysical activityTwo-sample mendelian randomization

Identifiers

PMID41165769

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.