Evidence map›Paper›PMID 41165614›Full record

ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2026

Associations between pain reactivity to worse sleep and health outcomes.

Christina X Mu, Brent J Small, Christina S McCrae, Lindsay J Peterson, Ross Andel, Katie L Stone, Soomi Lee

Abstract read
In one paragraph

Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Christina X MuDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States.ORCID 0000-0002-3528-0482
Brent J SmallSchool of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.ORCID 0000-0002-7444-4689
Christina S McCraeSleep and Health Innovations in Neurobehavioral (SHINE) Science Center, College of Nursing, University of South Florida, Tampa, Florida, United States.ORCID 0000-0003-4313-6867
Lindsay J PetersonSchool of Aging Studies, University of South Florida, Tampa, Florida, United States.ORCID 0000-0003-1129-0931
Ross AndelEdson College of Nursing and Health Innovation, Arizona State University, Tempe, Arizona, United States.ORCID 0000-0003-4083-4790
Katie L StoneDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States.ORCID 0000-0003-2797-3171
Soomi LeeDepartment of Human Development and Family Studies, Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, United States.ORCID 0000-0002-7623-3770

Funding

Translational Epidemiology - Training for Research on Aging and Chronic diseaseT32AG049663 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Elizabeth Rose Mayeda, Mark J Pletcher · 2016 to 2026
$5.8M
Protecting Healthcare Workers' Health and Well-being: The Joint Effects of Sleep and Pain, and Moderations by Work CharacteristicsF31HL165898 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI MU, CHRISTINA XUONG · 2022 to 2024
$70k
NHLBI NIH HHS F31 HL165898NHLBI NIH HHS F31HL165898NIA NIH HHS T32 AG049663NIA NIH HHS T32AG049663
6 · The paper itself

Abstract

objectivesSleep and pain are co-occurring issues in adulthood. "Pain reactivity to worse sleep" refers to person-specific changes in daily pain following nights of shorter-than-usual sleep duration or poorer-than-usual sleep quality. We examined the cross-sectional and longitudinal relationships between sleep-related pain reactivity with psychological distress and the number of chronic conditions.

methodsData were obtained from the Work, Family, and Health Study, which collected data from workers (n = 311; Mage = 41.38 years), who completed eight days of daily diary. We controlled for sociodemographic and health covariates in a series of multilevel structural equation models and growth curve models in Mplus. Sensitivity analyses adjusted for sleep and pain medications and stratified analyses by age.

resultsThose with higher pain severity reactivity to shorter sleep duration (B = 0.54, p < .001) and higher pain severity reactivity to poorer sleep quality (B = 0.58, p < .001) had more concurrent distress. In the growth curve models, pain reactivity to worse sleep was not associated with a change in distress or the number of chronic conditions. After controlling for sleep and pain medication use, higher pain reactivity to poorer sleep quality was associated with more concurrent distress, and contrary to hypotheses, higher pain location reactivity to poorer sleep quality was associated with a decrease in distress and fewer chronic conditions over time. DISCUSSION: Higher pain reactivity to worse sleep was associated with more concurrent distress but not distress over time or risk of chronic conditions. Future directions are to examine the influence of pain reactivity to worse sleep in larger and more diverse samples across longer follow-up.

Indexed as

PainPsychological DistressSleep QualitySleep Wake DisordersAdultChronic DiseaseCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedPain MeasurementChronic conditionsPain severityPerson-centered analysisPsychological distressReactivity

Identifiers

PMID41165614
PMCPMC12759003

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.