Evidence map›Paper›PMID 41165593›Full record

ArticleJournal of animal science2025

TET1-mediated DNA demethylation suppresses migration of goat placental trophoblast cells.

Zhipeng Sun, Yiping Tang, Yuhao Liao, Xiang Ma, Mingming Wang, Xingqiang Fang, Songjian Yang, Junyin Zhao, Yongju Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhipeng SunCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Yiping TangAnimal Nutrition Institute, Sichuan Agricultural University (SAU), Chengdu, 625014, China.
Yuhao LiaoCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Xiang MaCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Mingming WangCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Xingqiang FangCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.ORCID 0000-0002-9163-2104
Songjian YangCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Junyin ZhaoCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Yongju ZhaoCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.ORCID 0000-0001-9256-8856

Funding

Collection, Utilization and Innovation of Animal ResourcesFundamental Research Funds for the Central Universities SWU-XDJH202301National Key Research and Development Program of China 2022YFD1300202National Natural Science Foundation of China 31772564National Natural Science Foundation of China 32502862Research Institutes and Enterprises of ChongqingStrategic Collaboration Project of Chongqing Municipal People's Government and Chinese Academy of Agricultural Sciences
6 · The paper itself

Abstract

The placenta is essential for supporting fetal growth by delivering nutrients and removing waste products. Its development hinges on precise epigenetic regulation, yet the role of Ten-eleven translocation 1 (TET1) in ruminant trophoblast biology remains unclear. Here, we show that TET1 acts as a suppressor of goat placental trophoblast cells (GTCs) migration. Using immortalized GTCs, we induced TET1 overexpression via 20 ng/μL doxycycline (Dox) and achieved knockdown through shRNA (piLenti-shTET1-GFP-a). Overexpression of TET1 markedly reduced GTCs migration and viability, whereas knockdown enhanced migration, with these effects reversible by restoring TET1 expression using Dox. Mechanistically, TET1 influenced chemical changes to DNA that control gene activity, decreasing DNA methylation mark (5mC) while increasing hydroxymethylation mark (5hmC). Conversely, TET1 knockdown had the opposite effect on these marks. Our results establish TET1 as a key suppressor of goat trophoblast cell migration via DNA modifications, providing novel insights into placental development and potential strategies for improving reproductive efficiency in livestock.

Indexed as

Cell MovementDNA DemethylationDNA MethylationGoatsMixed Function OxygenasesPlacentaProto-Oncogene ProteinsTrophoblastsAnimalsFemalePregnancyMixed Function OxygenasesProto-Oncogene Proteinscell migrationepigenetic regulationgoatplacental trophoblast cellsTET1

Identifiers

PMID41165593
PMCPMC12620002

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.