Evidence map›Paper›PMID 41165563›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Caffeine-associated reduction in patent ductus arteriosus is mediated in part by adenosine receptor antagonism.

Stacey L Crockett, Rachel L Su, Deanna C Sekulich, Kierra A Goins, Adrienne Montero, Naoko Boatwright, Courtney D Berger, Michael T Yarboro, Bibhash C Paria, Jennifer L Herington and 6 more

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stacey L CrockettDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Rachel L SuDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Deanna C SekulichDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0009-0001-7920-772X
Kierra A GoinsDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Adrienne MonteroDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Naoko BoatwrightDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0009-0002-7421-4741
Courtney D BergerDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Michael T YarboroDepartment of Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, Tennessee, United States.
Bibhash C PariaDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Jennifer L HeringtonDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0001-7084-184X
Shajila SiricillaDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Bret A MettlerDivision of Pediatric Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
David P BichellDivision of Pediatric Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Beth J AllisonThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.ORCID 0000-0002-1060-513X
Jeff ReeseDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0001-8751-6146
Elaine L SheltonDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0003-0929-2882

Funding

Pharmacologic Contributors to Patent Ductus ArteriosusR01HL164327 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI REESE, JOHN JEFFREY · 2022 to 2025
$2.9M
Pharmacological Validation of Vascular KATP Channels for Modulating Ductus Arteriosus ToneR01HD099777 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENTON, JEROD S., SHELTON, ELAINE · 2020 to 2023
$2.3M
An Engineered Human Ductus Arteriosus Capable of Biomimetic Response to Vasoactive AgentsR01HD116762 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Leon Bellan, Elaine L. Shelton · 2025 to 2026
$1.1M
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD099777HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL163797NHLBI NIH HHS R01 HL164327NICHD NIH HHS R01 HD099777NICHD NIH HHS R01 HD116762
6 · The paper itself

Abstract

Persistent patency of the ductus arteriosus (PDA) is less frequent among infants treated with caffeine for apnea of prematurity. Caffeine acts to inhibit A

Indexed as

CaffeineDuctus ArteriosusDuctus Arteriosus, PatentPurinergic P1 Receptor AntagonistsReceptors, Purinergic P1AdenosineAnimalsCells, CulturedCyclic AMPDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMyocytes, Smooth MuscleAdenosineCaffeineCyclic AMPPurinergic P1 Receptor AntagonistsReceptors, Purinergic P1adenosineadenosine receptorapnea of prematuritycaffeineductus arteriosus

Identifiers

PMID41165563
PMCPMC12767631

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.