Crystallographic Study of DNA T-Junction via Crystal Engineering.

Xiang Li, Naseem Siraj, Ruojie Sha, Chengde Mao

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Crystallographic Study of DNA T-Junction via Crystal Engineering.Angewandte Chemie (International ed. in English) · 2025
Article

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Xiang Li *Purdue University, Department of Chemistry, West Lafayette, IN, 47907, USA.

Naseem Siraj *Purdue University, Department of Chemistry, West Lafayette, IN, 47907, USA.

Ruojie ShaNew York University, Department of Chemistry, New York, NY, 10003, USA.

Chengde MaoPurdue University, Department of Chemistry, West Lafayette, IN, 47907, USA.ORCID 0000-0001-7516-8666

Funding

NSF CCF-2107393

6 · The paper itself

Abstract

Engineering DNA crystals is the primary motivation for structural DNA nanotechnology. Among many potential applications, such crystals promise as a platform to precisely (in terms of both location and orientation) organize biomolecules into 3D crystals for X-ray crystallographic studies of the guest biomolecules. The crystal formation depends on rationally designed DNA frameworks instead of unpredictable interactions between the guest molecule themselves; thus, avoiding the crystallization problem of biomolecules. This approach was proposed 40 years ago, however, has not been realized so far. Herein, we report an effort along this direction to study DNA T-junction, a common DNA structure used in DNA nanoconstruction. This study is an initial demonstration of the feasibility of the 40-year-old proposal. We expect that it would be quickly adapted to study many other molecules, particularly nucleic acids (e.g., aptamers, catalytic DNAs/RNAs, ribozymes, and ribonucleoproteins) that are, otherwise, difficult to be studied.

Indexed as

DNACrystallizationCrystallography, X-RayModels, MolecularNanotechnologyNucleic Acid ConformationDNADNADNA crystal engineeringDNA nanostructuresDNA nanotechnology

Identifiers

PMID41165523

DOI10.1002/anie.202518174

PMCPMC12707366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.