Evidence map›Paper›PMID 41165505›Full record

ReviewChemistry & biodiversity2026

Molecular Roadmap of COVID-19: From Viral Entry to Therapeutic Targets.

Afeez Adekunle Ishola, Idris Adewale Ahmed, Maryam Abimbola Mikail

Abstract readReview
In one paragraph

Review in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Afeez Adekunle IsholaDevelopmental Therapeutics Branch (DTB) of the National Cancer Institute (NCI), National Institute of Health (NIH), Bethesda, Maryland, USA.
Idris Adewale AhmedDepartment of Biotechnology, School of Applied Science, Lincoln University College, Petaling Jaya, Selangor, Malaysia.ORCID https://orcid.org/0000-0002-2215-3900
Maryam Abimbola MikailDepartment of Biotechnology, School of Applied Science, Lincoln University College, Petaling Jaya, Selangor, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the global emergency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has subsided, the pandemic is not over, making the development of effective therapeutics crucial to reduce mortality and restore patient health. Identifying host molecular pathways targeted by the virus is essential for drug discovery, whether through repurposing existing drugs or developing new ones. This review examines the molecular mechanisms of SARS-CoV-2 infection, including signaling pathways, therapeutic targets, viral entry and replication strategies, and associated clinical features. It also discusses current global infection and mortality trends, clinical management, and prospects for drug development. Data were sourced from major scientific databases. Given the virus's high mutation rate and ongoing impact, multidisciplinary collaboration is needed. Plant-derived compounds and herbal medicines show promise as potential antiviral interventions against coronavirus disease 2019 (COVID-19). The information and data on COVID-19 were collated from various resources and literature databases such as PubMed, Science Direct, Wiley, Springer, Taylor and Francis, Scopus, Inflibnet, Google, and Google Scholar.

Indexed as

Antiviral AgentsCOVID-19 Drug TreatmentSARS-CoV-2Virus InternalizationCOVID-19HumansSignal TransductionAntiviral Agentscoronavirus disease 2019 (COVID‐19) | molecular pathways | pathophysiology | therapeutics | transmission

Identifiers

PMID41165505
PMCPMC13421950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.