Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Florian FriedrichInstitute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany.ORCID 0000-0001-5420-6184
Marat MeleshinDepartment of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University of Halle-Wittenberg, Kurt-Mothes-Straße 3a, 06120, Halle, Germany.ORCID 0000-0002-6887-0200
Niklas PapenkordtInstitute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany.ORCID 0000-0003-3420-0695
Lena GaitzschInstitute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany.ORCID 0000-0002-2084-0168
Isabel PruckerInstitute of Organic Chemistry, University of Freiburg, Albertstr. 21, 79104, Freiburg, Germany.ORCID 0000-0002-5794-6759
Marco BorsoBiomedical Center, Medizinische Fakultät, Ludwigs-Maximilians Universität, Großhaderner Str. 9, Plangegg-Martinsried, 82152, Germany.ORCID 0000-0001-7467-7960
Jan RuprechtInstitute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany.ORCID 0009-0003-2949-0250
Christopher VorreiterDepartment of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120, Halle, Germany.ORCID 0000-0002-6108-0994
Sabrina RastInstitute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany.
Lin ZhangInstitute of Biochemistry, University of Freiburg, Albertstr. 21, 79104, Freiburg, Germany.ORCID 0000-0001-5431-5006
Matthias SchiedelInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany.ORCID 0000-0001-7365-3617
Wolfgang SipplDepartment of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120, Halle, Germany.ORCID 0000-0002-5985-9261
Axel ImhofBiomedical Center, Medizinische Fakultät, Ludwigs-Maximilians Universität, Großhaderner Str. 9, Plangegg-Martinsried, 82152, Germany.ORCID 0000-0003-2993-8249
Henning J JessenInstitute of Organic Chemistry, University of Freiburg, Albertstr. 21, 79104, Freiburg, Germany.ORCID 0000-0002-1025-9484
Oliver EinsleInstitute of Biochemistry, University of Freiburg, Albertstr. 21, 79104, Freiburg, Germany.ORCID 0000-0001-8722-2893
Mike SchutkowskiDepartment of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University of Halle-Wittenberg, Kurt-Mothes-Straße 3a, 06120, Halle, Germany.ORCID 0000-0003-0919-7076
Manfred JungInstitute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany.ORCID 0000-0002-6361-7716
Funding
Deutsche Forschungsgemeinschaft 192904750
6 · The paper itself
Abstract
Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
From Pharmacophore to Warhead: NAD · full record | OpenQuestion