ArticleChemistry & biodiversity2026
HR-LCMS-Guided Phytochemical Profiling, Multi-Target Bioactivities, and In Silico Studies of Calophyllum apetalum Willd. Leaf Extracts.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- HR-LCMS-Guided Phytochemical Profiling, Multi-Target Bioactivities, and In Silico Studies of Calophyllum apetalum Willd. Leaf Extracts.Chemistry & biodiversity · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study provides a comprehensive investigation of the phytochemical composition and biological activity of Calophyllum apetalum leaf extract. Among the solvents examined, ethanol and methanol extracts possess major phytoconstituents, with methanol revealing the higher extractive value (10.45%). Several bioactive substances were found through high-resolution liquid chromatography mass spectrometry (HR-LCMS) analysis. The ethanolic extract had higher total phenolic (218.6 ± 4.16 mg gallic acid equivalent [GAE]/g) and flavonoid (256.5 ± 3.13 mg quercetin equivalent [QE]/g) contents, whereas the methanolic extract had higher terpenoid content (144.64 ± 2.03 mg LNE/g). The ethanolic extract had high antioxidant activity, including DPPH scavenging (58.47% ± 0.18%), phosphomolybdate (60.54% ± 0.15%), and metal chelation (64.91% ± 0.54%). The BSA assay demonstrated anti-inflammatory activity (59.07% ± 0.02%). At 100 µg/mL, the ethanolic extract demonstrated antibacterial action against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Bioassays using brine shrimp and hemolysis showed moderate toxicity. HeLa (54.38% ± 0.81%) and MCF-7 (51.37% ± 1.22%) cells showed reduced viability in the cytotoxicity assay by ethanolic extract. In silico docking confirmed strong binding affinities of the identified anticancer compounds to target proteins. This work presents novel HR-LCMS profiling and anticancer evaluation of C. apetalum leaf metabolites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.