Evidence map›Paper›PMID 41165411›Full record

ArticleJournal of bacteriology2025

The mevalonate pathway of isoprenoid biosynthesis supports metabolic flexibility in

Christine M Qabar, Edward E K Baidoo, Emine Akyuz Turumtay, Tariq M Qayum, Jay D Keasling, Cressida A Madigan, Daniel A Portnoy, Jeffery S Cox

Abstract read
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Integrating pharmacologically important flora into phytoremediation: The role of bacillus strains in mitigating chromium toxicity and enhancing rhizostabilization.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Christine M QabarDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, USA.ORCID 0000-0002-8345-9225
Edward E K BaidooJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California, USA.ORCID 0000-0001-5787-1219
Emine Akyuz TurumtayJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California, USA.ORCID 0000-0002-1504-4810
Tariq M QayumDepartment of Molecular Biology, University of California San Diego, La Jolla, California, USA.
Jay D KeaslingJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, California, USA.ORCID 0000-0003-4170-6088
Cressida A MadiganDepartment of Molecular Biology, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-3270-7142
Daniel A PortnoyDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, USA.ORCID 0000-0003-1218-2799
Jeffery S CoxDepartment of Molecular and Cellular Biology, University of California Berkeley, Berkeley, California, USA.ORCID 0000-0002-5061-6618

Funding

The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI PORTNOY, DANIEL A · 2004 to 2025
$45.5M
RESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Danielle L Swaney · 2018 to 2026
$21.4M
Systems Biology, Bioinformatics, & Data IntegrationU19AI162583 · NIAID · UNIVERSITY OF WASHINGTON · PI COX, JEFFERY S, HAWN, THOMAS R · 2021 to 2025
$13.0M
Listeria Hemolysis and Escape From a VacuoleR01AI027655 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DANIEL A PORTNOY · 1993 to 2026
$10.1M
Genetic Dissection of Cells and Organisms Training ProgramT32GM132022 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Nicole King, NOAH K WHITEMAN · 2019 to 2026
$5.2M
Bacterial disruption of neuroimmune pathways in a transparent brainDP2NS127277 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MADIGAN, CRESSIDA ARIANNA · 2021 to 2024
$2.4M
Reversing cancer immunosuppression using attenuated Listeria monocytogenesR01CA283604 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michel DuPage, DANIEL A PORTNOY · 2024 to 2026
$1.4M
National Institute of Allergy and Infectious Diseases 1P01AI063302National Institute of Allergy and Infectious Diseases 1R01AI027655National Institute of Allergy and Infectious Diseases U19AI135990National Institute of Allergy and Infectious Diseases U19AI162583NCI NIH HHS 5R01CA283604NCI NIH HHS R01 CA283604NIAID NIH HHS P01 AI063302NIAID NIH HHS R01 AI027655NIAID NIH HHS U19 AI135990NIAID NIH HHS U19 AI162583NIGMS NIH HHS T32 GM132022NIGMS NIH HHS T32GM132022NINDS NIH HHS 1DP2NS127277NINDS NIH HHS DP2 NS127277
6 · The paper itself

Abstract

Isoprenoids are a diverse class of natural products that are essential in all domains of life. Most bacteria synthesize isoprenoids through either the methylerythritol phosphate (MEP) pathway or the mevalonate (MEV) pathway, while a small subset encodes both pathways, including the pathogen

Indexed as

Mevalonic AcidMycobacterium marinumTerpenesAnimalsBacterial ProteinsErythritolGene Expression Regulation, BacterialMetabolic Networks and PathwaysMycobacterium Infections, NontuberculousBacterial ProteinsErythritolMevalonic AcidTerpenesdiversityisoprenoidmetabolismmethylerithritolmevalonatemycobacteriaMycobacterium marinumterpeneterpenoid

Identifiers

PMID41165411
PMCPMC12632256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.