ReviewChemical senses2025
Olfactory GPCRs through the lens of structural bioinformatics.
Review in Chemical senses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Olfactory perception, mediated by G protein-coupled receptors (GPCRs) such as odorant receptors (ORs) and trace amine-associated receptors (TAARs), plays a pivotal role in human health, influencing behaviors like food choices and serving as early biomarkers for neurodegenerative diseases. Despite their importance, olfactory GPCRs are among the least understood members of the GPCR superfamily, and most ORs and TAARs are still orphan receptors. This review provides a comprehensive overview of recent advancements in the structural bioinformatics of olfactory GPCRs. We outline how computational, structure-based strategies have succeeded in identifying novel modulators for olfactory receptors. By discussing recent breakthroughs in GPCR structural biology, such as the first resolved experimental structures of ORs and TAARs, and the transformative impact of AI-driven structure prediction tools for olfactory receptors, this review offers a roadmap for future olfaction pharmacology research.
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