Observational studyAlcohol and alcoholism (Oxford, Oxfordshire)2025
The level of response to alcohol is related to level of se-phosphate in the general population.
Observational study in Alcohol and alcoholism (Oxford, Oxfordshire), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA low subjective response to alcohol predicts increased consumption and risk for alcohol use disorder (AUD). While self-report tools like the self-rated effects of alcohol (SRE) questionnaire assess this, biological correlates remain understudied. This study investigates the relationship between SRE scores, serum phosphate (se-P), and other alcohol related measures using data from one experimental and two clinical cohorts. MATERIAL AND
methodsParticipants from three cohorts completed the SRE questionnaire. Blood samples were collected to measure alcohol use biomarkers and other blood measures like se-P. Statistical analyses assessed relationships between SRE scores and biochemical measures across groups.
resultsAUD patients had higher SRE lately scores (mean 6.74) than blood donors (3.08), and higher se-P (1.23 mmol/L vs. 1.05). SRE scores correlated positively with se-P in both the experimental group (r = 0.507, P = .027) and blood donors (r = 0.377, P = .011), but not in AUD patients. Prolactin correlated with SRE scores where measured. DISCUSSION: This study confirmed a positive correlation between se-P and SRE scores in non-AUD groups, possibly supporting a link between se-P and presystemic alcohol metabolism. No such relationship was found in AUD patients, possibly due to nutritional supplementation of phosphate and other nutrients. The observed association between prolactin and SRE in both observational groups was unexpected. Overall, these findings further indicate that se-P may play a role in alcohol metabolism, especially presystemic alcohol metabolism, but further research and replication are needed to clarify mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.