ReviewAmerican journal of reproductive immunology (New York, N.Y. : 1989)2025
Neutrophils at the Maternal-Fetal Interface: Agents of Protection or Destruction?
Review in American journal of reproductive immunology (New York, N.Y. : 1989), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Remodeling lesions locate at sites of strong extravillous trophoblast invasion and are associated with neutrophil presence in the human first-trimester decidua.Human reproduction (Oxford, England) · 2026Article
- TLR7 alters the maternal immune landscape during influenza A infection to increase maternal and fetal morbidity.Science advances · 2026Article
- Neutrophils at the Maternal-Fetal Interface: Agents of Protection or Destruction?American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Neutrophils, traditionally recognized for their role in innate immunity, have emerged as a key cell population at the maternal-fetal interface, during both uncomplicated and pathological pregnancies. Neutrophil effector functions, including phagocytosis, neutrophil extracellular trap formation, and degranulation, can play protective roles, such as preventing infection and facilitating tissue remodeling during pregnancy. However, these effector functions may also contribute to excessive inflammation, tissue damage, and adverse pregnancy outcomes in the context of sterile inflammation or maternal infection, underscoring the dual nature of neutrophils at the maternal-fetal interface. In this review, we examine the paradoxical nature of neutrophils at the maternal-fetal interface. Further, the protective and deleterious roles of neutrophils during pregnancy are evaluated in the context of bacterial, viral, and parasitic infections. Insights from this review are anticipated to inform basic and clinical research aimed at identifying neutrophils or neutrophil components as biomarkers and therapeutic targets in obstetric conditions and infectious diseases during pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.