Evidence map›Paper›PMID 41165278›Full record

ArticleCritical care explorations2025

The Epidemiology of ICU Readmissions Across Ten Health Systems.

Saki Amagai, Vaishvik Chaudhari, Kaveri Chhikara, Nicholas E Ingraham, Chad H Hochberg, Anna K Barker, Chengsheng Mao, Alexander C Ortiz, Gary E Weissman, Benjamin E Schmid and 12 more

Abstract read
In one paragraph

Article in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. [Readmission to the intensive care unit : A rare phenomenon or relevant to clinical practice?]Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Saki AmagaiDepartment of Preventive Medicine, Division of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-2825-4219
Vaishvik ChaudhariDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Rush University, Chicago, IL.
Kaveri ChhikaraDepartment of Medicine, Division of Pulmonary and Critical Care, University of Chicago, Chicago, IL.
Nicholas E IngrahamDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, MN.
Chad H HochbergDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Anna K BarkerDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI.
Chengsheng MaoDepartment of Preventive Medicine, Division of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL.
Alexander C OrtizDivision of Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Gary E WeissmanPalliative and Advanced Illness Research (PAIR) Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Benjamin E SchmidPalliative and Advanced Illness Research (PAIR) Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Megan SchwinneDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA.
Sivasubramanium V BhavaniDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University School of Medicine, Atlanta, GA.
Shan GuleriaDepartment of Medicine, Division of Pulmonary and Critical Care, University of Chicago, Chicago, IL.
Zewei LiaoDepartment of Medicine, Division of Pulmonary and Critical Care, University of Chicago, Chicago, IL.
Nikolay MarkovDivision of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL.
Patrick G LyonsDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, Portland, OR.
Brenna Park-EganDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, Portland, OR.
William F ParkerDepartment of Medicine, Division of Pulmonary and Critical Care, University of Chicago, Chicago, IL.
Yuan LuoDepartment of Preventive Medicine, Division of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL.
Juan C RojasDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Rush University, Chicago, IL.
Catherine A GaoDivision of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0001-5576-3943
Common Longitudinal ICU data Format (CLIF) Consortium

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
Improving the efficiency and equity of critical care allocation during a crisis with place-based disadvantage indicesR01LM014263 · NLM · UNIVERSITY OF CHICAGO · PI William F Parker · 2023 to 2026
$2.0M
High Performance Computing and Machine Learning Infrastructure for Oregon Life SciencesS10OD034224 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLROTT, KYLE · 2023 to 2023
$2.0M
Development and Validation of Correction Equations to Enhance Quality of Infrared TechnologyR01HL175626 · NHLBI · EMORY UNIVERSITY · PI Sivasubramanium Bhavani · 2025 to 2026
$1.1M
Identification of Precision Sepsis Subphenotypes Using Vital Sign TrajectoriesK23GM144867 · NIGMS · EMORY UNIVERSITY · PI BHAVANI, SIVASUBRAMANIUM · 2021 to 2025
$890k
SPOT-IT: Sepsis Prediction in Oncology Through Implementation Science and TechnologyK08CA270383 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrick G Lyons · 2024 to 2026
$851k
Mending a Broken Heart Allocation System with Machine LearningK08HL150291 · NHLBI · UNIVERSITY OF CHICAGO · PI PARKER, WILLIAM F · 2020 to 2024
$713k
Identifying Areas to Improve ICU Outcomes through Provider VariationK23HL166783 · NHLBI · UNIVERSITY OF MINNESOTA · PI Nicholas E Ingraham · 2023 to 2026
$645k
Machine learning to predict cure in severe pneumonia episodesK23HL169815 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Catherine A. Gao · 2024 to 2026
$501k
American Heart Association-American Stroke Association 24PRE1196998NCI NIH HHS K08 CA270383NHLBI NIH HHS K08 HL150291NHLBI NIH HHS K23 HL166783NHLBI NIH HHS K23 HL169815NHLBI NIH HHS R01 HL175626NHLBI NIH HHS T32 HL007891NIGMS NIH HHS K23 GM144867NIH HHS S10 OD034224NLM NIH HHS R01 LM014263
6 · The paper itself

Abstract

ICU readmissions remain a critical concern, carrying increased morbidity, mortality, and cost. We examined the epidemiology of unplanned ICU readmissions across 19 hospitals in the Common Longitudinal ICU data Format (CLIF) Consortium from January 2020 to December 2021 and the MIMIC-IV database. The cohort included 185,241 adult ICU admissions, excluding postoperative or post-interventional procedure readmissions. Overall, 8.6% of ICU discharges were readmitted during the same hospitalization. Unplanned readmissions occurred in 1.9% of cases within 24 hours, 3.4% within 48 hours, and 4.5% within 72 hours of discharge. Readmitted patients experienced markedly higher in-hospital mortality (20.6% vs. 2.1%; p < 0.001). Compared with initial ICU stays, readmissions were associated with greater use of respiratory support (42.3% vs. 35.3%) and vasopressors (26.1% vs. 23.1%). Hospitals with stepdown units demonstrated comparable unplanned ICU readmission rates. These findings demonstrate that ICU readmissions remain common, are associated with poor outcomes, and require greater organ support. Improved characterization of high-risk subphenotypes is needed to inform safer discharge processes.

Indexed as

Intensive Care UnitsPatient ReadmissionAdultAgedFemaleHospital MortalityHumansLength of StayMaleMiddle AgedPatient DischargeUnited Statescritical care outcomesdischarge risk stratificationhospital mortalityintensive care unit readmissionorgan support utilization

Identifiers

PMID41165278
PMCPMC12574502

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.