Evidence map›Paper›PMID 41165207›Full record

ArticleCancer science2026

lncDILC Downregulation in Liver Cancer-Associated Fibroblasts Drives Pro-Invasive Conversion via a miR-6071-ZNF395 Axis.

Yawen Li, Jilong Liu, Shentao Tai, Dandan Tong, Bifeng Wang, Dingbing Lu, Guoqing Shi, Xuemei Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yawen LiDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.ORCID https://orcid.org/0000-0003-2042-5834
Jilong LiuDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Shentao TaiDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Dandan TongDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Bifeng WangDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Dingbing LuDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Guoqing ShiDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Xuemei LiuDepartment of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.ORCID https://orcid.org/0000-0002-3104-4343

Funding

Excellent Youth Talent Training Program of Affiliated Hospital of Zunyi Medical UniversityGuizhou Provincial Science and Technology Program Qiankehe-jichu-ZK[2021]-yiban362National Natural Science Foundation of China 82160558Science and Technology Program of Zunyi City Zunshikehe-HZ(2020)-252
6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) play important roles in the progression of hepatocarcinoma, while the mechanism underlying the pro-invasive transformation of normal fibroblasts (NFs) to CAFs remains poorly defined. lncDILC is a long non-coding RNA previously identified to be downregulated in liver cancer stem cells. Here, we found that lncDILC was also significantly downregulated in liver cancer CAFs compared with NFs. Knockdown of lncDILC in NFs facilitated their conversion into CAFs, and enhanced the ability to promote the migration and invasion of liver cancer cells. Conversely, overexpression of lncDILC in CAFs ameliorated their invasive characteristics, and suppressed cancer cell metastasis. Moreover, we found miR-6071 acted as a target of lncDILC, and functioned as a transcriptive suppressor of zinc finger protein 395 (ZNF395), which exhibited an inhibitory effect on the pro-invasive conversion of fibroblasts. Overexpression of ZNF395 reversed the pro-invasive effects induced by lncDILC knockdown. These results elucidate a pathway of lncDILC-miR-6071-ZNF395 that suppresses the NF-CAF conversion, suggesting new therapeutic targets for the strategies for the treatment of liver cancer.

Indexed as

Cancer-Associated FibroblastsCarcinoma, HepatocellularDNA-Binding ProteinsLiver NeoplasmsMicroRNAsRNA, Long NoncodingTranscription FactorsAnimalsCell Line, TumorCell MovementDown-RegulationGene Expression Regulation, NeoplasticHumansMiceNeoplasm InvasivenessDNA-Binding ProteinsMicroRNAsRNA, Long NoncodingTranscription Factorscancer‐associated fibroblastshepatocellular carcinomalong non‐coding RNAmicroRNApro‐invasive transformation

Identifiers

PMID41165207
PMCPMC12775580

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.