Evidence map›Paper›PMID 41165094›Full record

ArticlePsychological medicine2025

Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study.

Mahnoor Hyat, Jinhan Zhu, Toni A Boltz, Matthew P Conomos, Dylan E Hughes, Alison E Fohner, Katherine T Foster, Tim B Bigdeli, Jennifer K Forsyth

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In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahnoor HyatDepartment of Psychology, https://ror.org/00cvxb145University of Washington, Seattle, WA, USA.ORCID 0000-0001-8039-4860
Jinhan ZhuDepartment of Psychology, https://ror.org/00cvxb145University of Washington, Seattle, WA, USA.
Toni A BoltzStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0226-7924
Matthew P ConomosDepartment of Biostatistics, https://ror.org/00cvxb145University of Washington, Seattle, WA, USA.ORCID 0000-0001-9744-0851
Dylan E HughesDepartment of Psychology, University of California, Los Angeles, CA, USA.ORCID 0009-0003-3759-2417
Alison E FohnerDepartment of Epidemiology, https://ror.org/00cvxb145University of Washington, WA, USA.ORCID 0000-0003-4231-3331
Katherine T FosterDepartment of Psychology, https://ror.org/00cvxb145University of Washington, Seattle, WA, USA.ORCID 0000-0002-3561-6687
Tim B BigdeliDepartment of Psychiatry and Behavioral Sciences, Institute for Genomics in Health, https://ror.org/0041qmd21State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.ORCID 0000-0003-2215-5946
Jennifer K ForsythDepartment of Psychology, https://ror.org/00cvxb145University of Washington, Seattle, WA, USA.

Funding

Genetic Risk for Serious Mental Illness and DevelopmentR01MH127165 · NIMH · UNIVERSITY OF WASHINGTON · PI Jennifer Katherine Forsyth, Juan David Palacio · 2022 to 2026
$3.4M
NIMH NIH HHS R01 MH127165NIMH NIH HHS R01MH127165
6 · The paper itself

Abstract

backgroundSubtle behavioral and cognitive symptoms precede schizophrenia (SCZ) and appear in individuals with elevated risk based on polygenic risk scores (SCZ-PRS) and family history of psychosis (SCZ-FH). However, most SCZ-PRS studies focus on European ancestry youth, limiting generalizability. Furthermore, it remains unclear whether SCZ-FH reflects common-variant polygenic risk or broader SCZ liability.

methodsUsing baseline data from the Adolescent Brain Cognitive Development (ABCD) study, we investigated associations of SCZ-FH and SCZ-PRS with cognitive, behavioral, and emotional measures from NIH-Toolbox, Child Behavior Checklist (CBCL), and Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS) for 9,636 children (mean age = 9.92 yrs, 47.4% female), specifically, 5,636 European, 2,093 African, and 1,477 Admixed American ancestry individuals.

resultsSCZ-FH was associated with SCZ-PRS (

conclusionsSCZ-FH showed associations with broad psychopathology, while SCZ-PRS was associated with cognition and specific symptoms in European youth. Findings highlight their complementary role in SCZ risk assessment and the need to improve PRS utility across ancestries.

Indexed as

Black or African AmericanEuropean PeopleMultifactorial InheritancePsychotic DisordersSchizophreniaWhiteAdolescentChildFemaleGenetic Predisposition to DiseaseHumansMaleUnited StatesABCD studychildhoodcognitionearly signsfamily historypolygenic risk scores (PRS)psychopathologyschizophreniasymptoms

Identifiers

PMID41165094
PMCPMC13054910

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.