Evidence map›Paper›PMID 41164999›Full record

ReviewExpert review of respiratory medicine2026

Amanda C Zangirolami, Aaron B Benjamin, Hatice Ceylan Koydemir, Wenshe R Liu, Jeffrey D Cirillo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert review of respiratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amanda C ZangirolamiDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
Aaron B BenjaminDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
Hatice Ceylan KoydemirDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.
Wenshe R LiuDepartment of Chemistry and Department of Biochemistry and Biophysics, Texas A&M University, Bryan, TX, USA.
Jeffrey D CirilloDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.

Funding

Use of the Noncanonical Amino Acid Mutagenesis Technique in Combination with Other Approaches to Study Functions of Posttranslational Lysine Modifications in ProteinsR35GM145351 · NIGMS · TEXAS A&M UNIVERSITY · PI Wenshe Ray Liu · 2022 to 2026
$2.6M
Ultrasensitive detection of Mycobacterium tuberculosis infectionR01AI186092 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Jeffrey D. Cirillo · 2024 to 2026
$2.2M
NIAID NIH HHS R01 AI186092NIGMS NIH HHS R35 GM145351
6 · The paper itself

Abstract

introductionTuberculosis (TB), caused by AREAS COVERED: Imaging technologies that can quantify viability and infectious load can have a profound impact on progress toward new therapeutics and vaccines and allow rapid diagnosis. Although imaging can quantify bacterial loads throughout an entire animal in real-time, sensitivity is a key limitation. Fluorescent and bioluminescent recombinant strains have been used within the TB field and in other bacteria but have a threshold of ~10 EXPERT OPINION: Recombinant reporter systems for imaging bacteria should continue to improve and may reach similar thresholds, but at present, REF remains the most sensitive approach. Furthermore, new more sensitive probes can be readily developed, suggesting that REF will ultimately allow detection of single bacteria in an infected host.

Indexed as

Fluorescent DyesLuminescent MeasurementsMycobacterium tuberculosisOptical ImagingTuberculosisAnimalsBacterial Loadbeta-LactamasesGenes, ReporterHumansMicePredictive Value of Testsbeta-LactamasesFluorescent Dyesanimal modelsbacillus Calmette–Guérin (BCG)bioluminescencefluorescenceMycobacterium tuberculosisOptical imagingrespiratory infectionβ-lactamase

Identifiers

PMID41164999
PMCPMC12604640

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.