Evidence map›Paper›PMID 41164971›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation.

Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jingqi ShiBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Qingyu LiBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Jian LiBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Jian BaiBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Ji XiBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Qi HeBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Jianglin ZhouBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Xuejun WangBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Xiang SongBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Xiaoju LiBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Xiangpei YueBeijing Institute of Basic Medical Sciences, Beijing, 100191, P. R. China.
Xiaochang ZhangBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Zhen SunBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Jiangbo LiBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Wen YangBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Yuke CuiBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Wenjie ShuBioinformatics Center of AMMS, Beijing, 100850, P. R. China.
Liang GuoBioinformatics Center of AMMS, Beijing, 100850, P. R. China.ORCID https://orcid.org/0000-0002-8748-5770
Shengqi WangBioinformatics Center of AMMS, Beijing, 100850, P. R. China.

Funding

National Natural Science Foundation of China 32300127National Natural Science Foundation of China 32500695National Natural Science Foundation of China 81830101
6 · The paper itself

Abstract

Hepatic intercellular communication is the driving force for the progression of chronic Hepatitis B virus (CHB)-associated hepatopathologies, with the dynamic molecular mechanisms largely unknown. Combining scRNA-seq and spatial transcriptomic analysis, the kinetic landscape of the liver microenvironment across time and space in AAV-HBV mice, which develop from inflammation to ultimately hepatocellular carcinoma is generated. Kupffer cells (KCs), originally resided within the peri-portal area, are persistently recruited to the HBV-enriched peri-central region via increased CXCL9 produced by endothelial cells, facilitating the interaction between KCs and HBV

Indexed as

Hepatitis B, ChronicKupffer CellsLipid Metabolism DisordersLiver NeoplasmsLiver X ReceptorsNeoplastic Stem CellsAnimalsCarcinoma, HepatocellularHepatitis B virusHepatocytesHumansLipid MetabolismMiceMice, Inbred C57BLLiver X ReceptorsNR1H3 protein, humanNr1h3 protein, mousechronic HBVinflammation‐to‐carcinoma transitionKupffer celllipid metabolism disorderLXRα

Identifiers

PMID41164971
PMCPMC12915127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.