Observational studyAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Subclinical vascular burden in relation to cognitive decline and impairment: The Multi-Ethnic Study of Atherosclerosis (MESA).
Observational study in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Heterogeneity in the association between cardiovascular disease and cognitive decline: a pooled analysis of five prospective cohort studies from 24 countries.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Lacunes with Risk Factors, Cognition, and Atrophy: The Multi-Ethnic Study of Atherosclerosis (MESA).medRxiv : the preprint server for health sciences · 2026Article
- Association between the atherogenic index of plasma and cognitive impairment.Scientific reports · 2026Article
- Subclinical vascular burden in relation to cognitive decline and impairment: The Multi-Ethnic Study of Atherosclerosis (MESA).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
introductionSubclinical cardiovascular disorders may be differentially associated with cognitive function, decline, and impairment and point to pathways linking vascular disorders to dementia.
methodsThe Multi-Ethnic Study of Atherosclerosis (MESA) collected detailed subclinical vascular measures at baseline in 6814 participants with follow-up clinical examinations over 20 years. Baseline subclinical vascular measures aggregated into four uncorrelated factor composites: atherosclerosis, arteriosclerosis, blood pressure, and cardiac function. Cognitive performance was measured 10 years after baseline, repeated twice over the subsequent decade, along with detailed cognitive testing and adjudication.
resultsHigher baseline arteriosclerosis and atherosclerosis scores predicted greater cognitive decline, lower performance across multiple domains, and higher odds of mild cognitive impairment and dementia 20 years later. Associations were weaker for cardiac function and blood pressure composites. Stratified analyses confirmed generalizability across subgroups. DISCUSSION: Arteriosclerosis and atherosclerosis were more consistently associated with cognitive impairment and decline than cardiac function and blood pressure in a diverse population over 20 years. HIGHLIGHTS: Subclinical factor relationships varied by cognitive domain and race/ethnicity. These observed associations were independent of clinical risk for dementia. Arteriosclerosis most consistently associated with cognitive function and decline.
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Registered trials
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