Evidence map›Paper›PMID 41164879›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2026

RIPK3 Protects Against Endothelial Activation and Vascular Permeability in a Mouse Model of Ischemia-Reperfusion Injury.

Charmain F Johnson, Christopher M Schafer, Kathryn Y Burge, Brian G Coon, Hala Chaaban, Courtney T Griffin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Charmain F JohnsonCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (C.F.J., C.M.S., B.G.C., C.T.G.).ORCID 0000-0002-6659-7298
Christopher M SchaferCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (C.F.J., C.M.S., B.G.C., C.T.G.).ORCID 0000-0002-5859-7714
Kathryn Y BurgeNeonatal-Perinatal Medicine, Department of Pediatrics (K.Y.B., H.C.), University of Oklahoma Health Sciences Center, Oklahoma City.ORCID 0000-0003-4128-5383
Brian G CoonCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (C.F.J., C.M.S., B.G.C., C.T.G.).
Hala ChaabanNeonatal-Perinatal Medicine, Department of Pediatrics (K.Y.B., H.C.), University of Oklahoma Health Sciences Center, Oklahoma City.ORCID 0000-0002-7112-564X
Courtney T GriffinCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City (C.F.J., C.M.S., B.G.C., C.T.G.).ORCID 0000-0001-8100-3171

Funding

Viral sensor IFIH1 promotes SLE through an altered interferon programP20GM139763 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI Audrey Cleuren · 2021 to 2026
$20.3M
Protease-Mediated Vascular Instability in Development and DiseaseR35HL144605 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GRIFFIN, COURTNEY T · 2019 to 2025
$5.9M
American Heart Association-American Stroke Association 20POST35120396NHLBI NIH HHS R35 HL144605NIGMS NIH HHS P20 GM139763
6 · The paper itself

Abstract

backgroundRIPK3 (receptor-interacting protein kinase 3) has context-specific roles that are frequently associated with cellular damage and death. We previously found that hypoxia can trigger elevated levels of RIPK3 in endothelial cells (ECs), which contributes to lethal vascular rupture during mouse embryonic development. However, it is unknown whether elevated RIPK3 likewise compromises endothelial barrier function in adult vasculature under hypoxic conditions such as ischemia-reperfusion (I/R) injury.

methodsTwelve-week-old male and female littermate control or inducible EC-specific

results

conclusionsEndothelial RIPK3 suppresses EC activation and inflammation associated with IL-6 and VCAM-1 elevation to protect the vascular barrier in the context of intestinal I/R injury. Thus, endothelial RIPK3 plays surprisingly beneficial roles that reduce I/R injury-induced vascular dysfunction.

Indexed as

Capillary PermeabilityEndothelial CellsReceptor-Interacting Protein Serine-Threonine KinasesReperfusion InjuryAnimalsCells, CulturedDisease Models, AnimalFemaleInflammation MediatorsInterleukin-6MacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionInflammation MediatorsInterleukin-6interleukin-6, mouseReceptor-Interacting Protein Serine-Threonine KinasesRipk3 protein, mouseTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1cytokinesinflammationinterleukin-6micemonocytes

Identifiers

PMID41164879
PMCPMC12696878

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.