ArticleClinical ophthalmology (Auckland, N.Z.)2025
Prevalence of Dry Eye Disease and Ocular Surface Abnormalities in Eyes with Corneal Transplantation: A Cross-Sectional Study.
Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To evaluate tear film and ocular surface parameters and estimate the prevalence of dry eye disease (DED) in eyes following corneal transplantation. Patients and Methods: This cross-sectional study assessed 104 eyes of 81 patients who had undergone penetrating keratoplasty (PK; 81 eyes), deep anterior lamellar keratoplasty (DALK; 9 eyes), or endothelial keratoplasty (EK; 14 eyes) for ≥ 3 months. Comprehensive ocular surface evaluations included the Ocular Surface Disease Index (OSDI), tear osmolarity, tear meniscus height (TMH), fluorescein tear breakup time, Oxford fluorescein staining, eyelid margin morphology, Schirmer I test, meibomian gland expressibility, and meibum quality. Results: Among post-PK/DALK eyes, more than 50% demonstrated at least one significant ocular surface abnormality, whereas this was observed in at least 25% of post-EK eyes. Elevated tear osmolarity was detected in approximately 20% of eyes in both groups. Based on TFOS DEWS II criteria, 32% of post-PK/DALK eyes and 57% of post-EK eyes met the diagnostic threshold for DED. Post-PK/DALK eyes with a follow-up time of ≤ 6 months exhibited significantly higher Oxford staining scores compared to those with follow-up > 6 months ( Conclusion: DED is common after corneal transplantation. While more pronounced in the early postoperative period, ocular surface epitheliopathy may persist long-term after surgery. These findings underscore the need for proactive long-term ocular surface monitoring and management to optimize surgical outcomes.
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