ArticleJournal of pharmacy & bioallied sciences2025
Curcumin-loaded Nanofibers versus Metronidazole Gel in the Treatment of Chronic Periodontitis: A Double-blind, Randomized Controlled Trial.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Chronic periodontitis is a prevalent inflammatory disease that necessitates effective treatment strategies. This study aimed to compare the efficacy of curcumin-loaded nanofibers with metronidazole gel in treating chronic periodontitis. Methods: A double-blind, randomized controlled trial was conducted involving patients diagnosed with chronic periodontitis. Participants were randomly assigned to receive either curcumin-loaded nanofibers or metronidazole gel as an adjunct to scaling and root planning. Clinical parameters were assessed at baseline, one month, and three months post-treatment. Results: Both treatment groups exhibited significant improvements in probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) at all follow-up intervals compared to baseline. Notably, the curcumin-loaded nanofiber group demonstrated statistically significant greater reductions in PD and CAL at three months compared to the metronidazole gel group ( Conclusion: Curcumin-loaded metronidazole was used in nanofibers technology on chronic periodontitis patients, showing the possibility of improving therapeutic results, especially in posteriori periods, compared to the conventional metronidazole gel.
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