Evidence map›Paper›PMID 41164593›Full record

ArticleJournal of pharmacy & bioallied sciences2025

PCNA and MCM 2 in Odontogenic Tumors: An Immunnohistological Study.

Sarat K Nayak, Mitali Dash, Anshuman Shetty, R S Gayathri Priyadarshini, Mangesh S Panakaje, Mohammed Ibrahim, Heena Dixit

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Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sarat K NayakDepartment of Oral and Maxillofacial Pathology and Microbiology, S. C. B. Dental College, Cuttack, Odisha, India.
Mitali DashDepartment of Pathology, S. C. B. Medical College, Cuttack, Odisha, India.
Anshuman ShettyDepartment of Conservative Dentistry and Endodontics, A. B. Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Mangaluru, Karnataka, India.
R S Gayathri PriyadarshiniDepartment of Pathology, Sree Balaji Medical College and Hospital, BIHER University, Chennai, Tamil Nadu, India.
Mangesh S PanakajeDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, A. B. Shetty Memorial Institute of Dental Sciences, (A Constituent College of Nitte Deemed to be University), Mangalore, Karnataka, India.
Mohammed IbrahimDepartment of Oral and Maxillofacial Surgery, College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia.
Heena DixitDepartment of Psychology, Andhra University, Visakhapatnam, Andhra Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The proliferative potential of odontogenic tumors is an important factor in understanding their aggressive behavior. "Proliferating Cell Nuclear Antigen (PCNA)" is a functional and structural component of DNA replication factor, while "Minichromosome Maintenance Protein 2 (MCM2)", from the MCM family, mediates cell proliferation as well as progression through to S-phase. Here, we aimed to evaluate the expression of PCNA and MCM2 in odontogenic tumors with a special emphasis on ameloblastomas and "keratocystic odontogenic tumors (KCOTs)". Materials and Methods: Immunohistochemical staining for PCNA and MCM2 was performed in tissue samples of ameloblastoma and KCOT. The expression levels were studied. Results: Both PCNA and MCM2 were overexpressed significantly higher in ameloblastomas compared to KCOT. A strong correlation was also noted between increased MCM2 expression and local invasiveness of tumour ( Conclusions: We have studied the expression of MCM2 in a series of ameloblastomas (using an immunohistochemical method) and found this marker to be expressed at high levels; thus, it could potentially serve as a prognostic marker for these aggressive tumors.

Indexed as

AmeloblastomaimmunohistochemistryMCM2odontogenic tumorsPCNA

Identifiers

PMID41164593
PMCPMC12563898

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