ArticleJournal of pharmacy & bioallied sciences2025
Modulating Propofol Requirement for Induction: The Impact of Different Time Intervals of Fentanyl Administration.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: The administration timing of fentanyl influences the required dose of propofol and its associated hemodynamic responses and side effects during anesthesia induction. Objectives: The objective is to determine the total propofol dose necessary for loss of consciousness during induction. Materials and Methods: This randomized study included 68 patients (`I) aged 18-65 years undergoing elective surgery under general anesthesia. Two groups were formed: Group A received fentanyl (2 mcg/kg) five minutes before propofol induction, while Group B received it 7 min prior. The required propofol dose and hemodynamic parameters were recorded. Data analysis was conducted using SPSS, with a Results: Demographic characteristics were similar across both groups. Group A required a significantly higher propofol dose (86.77 mg ± 13.19 mg) than Group B (55.43 mg ± 13.01 mg). Incidence of movement (88.8% vs. 11.4%), vocalization (92.6% vs. 7.9%), and bucking (91.2% vs. 9.8%) were all higher in Group A ( Conclusion: Administering fentanyl 7 min before propofol significantly reduces propofol dosage requirements and minimizes hypotension incidence during induction.
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