ArticleJournal of pharmacy & bioallied sciences2025
Long-Term Outcomes of Periodontal Interventions in Children with Leukemia: A Retrospective Analysis.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background: Leukemia and its treatment compromise oral health, increasing periodontal disease risk in children. This study evaluated the long-term effects of periodontal interventions in children with leukemia. Methods: We reviewed records of 85 children with leukemia receiving periodontal treatment at People's Dental Academy (2010-2020). Data included demographics, leukemia subtype (Acute Lymphoblastic Leukemia [ALL], Acute Myeloid Leukemia [AML], others), chemotherapy, Hematopoietic Stem Cell Transplantation [HSCT] history, periodontal diagnosis (gingivitis, periodontitis), interventions (scaling/root planing, surgery), and clinical parameters (Pocket Depth [PD], Clinical Attachment Level [CAL], Bleeding on Probing [BOP], radiographic bone loss) at baseline, one, three, and five years. Patients with ≥ three-year follow-up were included. Data were analyzed using descriptive statistics and repeated measures analysis of variance (ANOVA). Results: The cohort comprised 45 ALL, 30 AML, and 10 other leukemia subtypes. At baseline, 70% had gingivitis, 30% periodontitis. Scaling/root planing was most common. At one year, PD (3.2 mm to 2.5 mm, Conclusions: Even after chemotherapy or HSCT, periodontal interventions sustain long-term periodontal health in children with leukemia. The importance of maintaining, as well as comprehensive oral health care and periodontal therapy stares at us from the five-year follow-up data. These results also illustrate the scant literature available on the long-term periodontal effects on these patients, pertaining to integrated dental practices. Further longitudinal research is warranted to confirm these results and identify additional risk factors.
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