Evaluating Therapeutic Efficacy of Bamboo Salt Mouthwash Compared to Benzydamine Hydrochloride Mouthwash for Recurrent Aphthous Ulceration: A Double-blind Randomized Clinical Trial.

Objective: There is no evidence regarding the efficacy of bamboo salt in the treatment of recurrent aphthous ulceration. The objective of the present study was to investigate the effect of bamboo salt mouthwash in comparison to benzydamine hydrochloride in the treatment of recurrent aphthous ulceration. Methods: This randomized double-blind clinical trial was performed on 40 patients diagnosed with minor recurrent aphthous ulceration. Patients were randomized to use bamboo salt or benzydamine mouthwashes for 5 days. Patients in both groups were instructed to use 30 mL of mouthwash every 8 h for 30 s each day. Study outcomes, comprising ulcer size, pain, healing time, and patients' satisfaction, were recorded by investigators. Findings: The adjusted between-group analyses showed that the mean ulcer size reduction was significantly greater in the bamboo salt group than the benzydamine hydrochloride group (mean difference: -1.40 ± 0.53; Conclusion: The present study demonstrated that the mouthwash of bamboo salt may be considered an effective option in the management of recurrent aphthous ulceration. However, further studies are needed to confirm our findings.