SynthesisFrontiers in nutrition2025
The effects of sarcopenia on the prognosis of patients with acute-on-chronic liver failure: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Acute-on-chronic liver failure following pneumonia in an elderly woman with metabolic dysfunction-associated steatotic liver cirrhosis.Clinical journal of gastroenterology · 2026Article
- Skeletal Muscle Density as an Independent Predictor of Prolonged Postoperative Hospital Stay After Surgery for Acute Cholecystitis.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Sarcopenia is an important indicator affecting the prognosis of patients with end-stage liver disease. The purpose of this review is to systematically review all relevant studies to evaluate the impact of sarcopenia on the prognosis of patients with ACLF. Methods: We systematically searched PubMed, Web of Science, Embase, the Cochrane Library, China Biomedical Literature Service System (CINAHL), China National Knowledge Infrastructure (CNKI), the WeiPu (VIP) and the Wanfang database for relevant articles published on or before August 1, 2024. Two independent reviewers conducted literature screening against predefined inclusion/exclusion criteria. Results: The systematic review included 12 cohort studies, with a total of 2,505 participants. Of these, 11 studies (2,072 participants) met the criteria for inclusion in the meta-analysis. The meta-analysis demonstrated that sarcopenia is significantly associated with an increased mortality risk in patients with ACLF [HR = 1.27, 95%CI (1.05, 1.54), Conclusion: The meta-analysis of 11 studies (2,072 participants) revealed a significant association between sarcopenia and elevated mortality risk in ACLF patients. However, these findings should be interpreted with caution due to the limited number of included studies and higher heterogeneity in the analysis. Systematic review registration: CRD42023441039.
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