Evidence map›Paper›PMID 41164349›Full record

ArticlePlastic and reconstructive surgery. Global open2025

Elysee Exosome Versus Cellbooster Lift in Oral Wound Healing.

Noury Adel, Nenad Stankovic, Amira Gindi, Jack Kolenda, Natalia Mikhaylova, Tamar Miladze, Gerardo Cervantes, Alyaa Ragaei, Lamiaa Mohamed Shawky, Mona Abdallah Sabry

Abstract read
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noury AdelOral and Maxillofacial Surgery Specialist, Private Practice, Cairo, Egypt.
Nenad StankovicPrivate Practice, Belgrade, Serbia.
Amira GindiPrivate Practice, Toronto, Canada.
Jack KolendaDepartment of Otolaryngology Head and Neck Surgery, University of Toronto, Toronto, Canada.
Natalia MikhaylovaPrivate Practice, Lausanne, Swtizerland.
Tamar MiladzePrivate Practice, Tbilisi, Georgia.
Gerardo CervantesPrivate Practice, Valencia, Spain.
Alyaa RagaeiDepartment of Histology and Biology, Saxony Egypt University for Applied Sciences and Technology, Cairo, Egypt.
Lamiaa Mohamed ShawkyDepartment of Histology and Biology, Benha Faculty of Medicine, Benha University, Benha, Egypt.
Mona Abdallah SabryDepartment of Surgery and Oral Medicine, Oral & Dental Research Institute National Research Centre, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The objective of this study was to evaluate the efficacy of injecting Elysee exosomes or Cellbooster Lift in promoting the healing of oral mucosal wounds. Methods: Thirty-six adult Wistar Albino rats were randomly divided into 3 groups. Group 1 served as the control group and underwent a scalpel incision in the oral mucosa without any intervention. Group 2 received an injection of Cellbooster Lift immediately after the incision, whereas group 3 was treated with Elysee exosomes. Biopsy samples were collected at baseline, as well as on the 7th and 14th postoperative days, for histological analysis. Hematoxylin and eosin staining was used to assess epithelial regeneration, whereas Masson trichrome staining was utilized to evaluate collagen formation and granulation tissue organization. Results: Both the Cellbooster Lift and Elysee exosome-treated groups showed improvements in wound healing compared with the control group. Both treatments accelerated healing, evidenced by increased collagen deposition and well-organized granulation tissue. Although the clinical outcomes were comparable between the Cellbooster Lift and Elysee exosome groups, histological analysis revealed that exosomes led to advanced epithelial regeneration and collagen formation, indicating their enhanced efficacy in promoting wound recovery. Conclusions: The injection of either Elysee exosomes or Cellbooster Lift enhanced the healing of oral mucosal wounds, with both treatments showing clinically similar improvements in recovery and tissue regeneration. However, histologically, exosomes demonstrated acceptable results, particularly in epithelial regeneration and collagen formation. These findings suggest that both therapies could be effective for oral wound healing, with exosomes offering an enhanced regenerative potential.

Identifiers

PMID41164349
PMCPMC12560693

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.