Variability in individual musculoskeletal response is not increased by countermeasures during bed rest.

Introduction: Under weightlessness conditions, there is a loss of bone and muscle mass. However, these adaptations are subject to great inter-individual variability. As an analogue to weightlessness, bed rest studies are carried out on Earth, which also serve to test countermeasures counteracting bone and muscle loss. Since study participants react differently to any interventions such as countermeasures, it can be assumed from a statistical point of view that the between-subject variation (BSV) is inflated when combining bed rest with countermeasure exercises. The aim of this study was therefore to examine whether a countermeasure has an effect on the magnitude of BSV. Methods: To this purpose, the decrease in muscle cross-sectional area and bone mineral content was analyzed at different measurement sites of 123 subjects in the control and intervention groups from six bed rest studies that tested different countermeasures. A novel statistical approach was chosen enabling quantification of the specific amount of variability after countermeasures ( Results: The comparison of the observed variability ( Conclusion: But rather, the extent to which, the astronaut reacts to unloading is the main factor influencing variability.