ReviewChemical science2025
Histone probes for reader and eraser investigations.
Review in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone modifications critically regulate chromatin architecture, gene transcription, and epigenetic inheritance. These modifications are dynamically regulated by writers and erasers. In addition, readers recognize site-specific histone marks to mediate downstream cellular activities. Therefore, precise identification and functional investigation of these regulatory enzymes and proteins are essential for elucidating the biological roles of histone modifications. Chemical probes, due to their target-specificity, serve as indispensable tools for investigating readers and erasers in chemical biology. This perspective summarizes the previous and cutting-edge development of histone probes. We first discuss affinity-based probes, which exploit binding interactions to proteins of interest (POIs) but suffer from limited efficacy for enrichment of low-abundance proteins and proteins with transient interactions. Covalent crosslinking probes could overcome these limitations. We thus next introduce photoreactive probes that crosslink POIs from highly reactive intermediates generated under UV irradiation. In addition, we summarize activity-based probes that selectively bind and crosslink readers and erasers inside pockets due to the unique warheads. At the end, we discuss our perspective on the field in the future, touching on key challenges and emerging directions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.