ArticleJournal of inflammation research2025
Novel Inflammatory Markers and Their Association with the Severity of Hypertriglyceridemia-Associated Acute Pancreatitis.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dynamic BUN patterns in the ICU: risk stratification and prognosis following cardiac surgery.Journal of cardiothoracic surgery · 2026Article
- A clinical study on the application of new inflammatory markers SII, SIRI, AISI, and MII in the identification of severe acute pancreatitis.Frontiers in medicine · 2026Article
- Development and Validation of an Early Severity Prediction Model for Hypertriglyceridemia-Associated Acute Pancreatitis: A Multicenter Cohort Study.Journal of inflammation research · 2026Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate associations between novel inflammatory biomarkers and disease severity in Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) and to evaluate their prognostic utility for risk stratification. Methods: This retrospective cohort study included 340 HTG-AP patients. Neutrophil-to-high-density lipoprotein Cholesterol Ratio (NHR), Monocyte-to-High-Density Lipoprotein Cholesterol Ratio (MHR), Lymphocyte-to-HDL cholesterol ratio (LHR), Platelet-to-high-density lipoprotein cholesterol ratio (PHR), Systemic Immune-Inflammation Index (SII), Systemic Inflammatory Response Index (SIRI), and aggregate index of systemic inflammation (AISI) indices were calculated. Multivariable logistic regression (unadjusted/age-sex-adjusted/fully-adjusted models) was conducted, and ROC analysis was performed to determine the predictive performance for MSAP+SAP/SAP. Results: Among 340 HTG-AP patients (156 MAP, 130 MSAP, 54 SAP), novel inflammatory markers NHR, SII, SIRI, MHR, PHR, and AISI significantly increased with severity ( Conclusion: NHR is a novel independent predictor of moderate-severe or severe HTG-AP, with the highest tertile conferring a 6.03-fold increased risk (95% CI: 2.98-12.19;
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