Evidence map›Paper›PMID 41164165›Full record

SynthesisFrontiers in medicine2025

Molecular exploration of host-pathogen interactions in severe

Francesco Messina, Claudia Rotondo, Luiz Ladeira, Sara Crosetti, Michele Properzi, Valentina Dimartino, Benedetta Riccitelli, Bernard Staumont, Giovanni Chillemi, Liesbet Geris and 2 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesco Messina *Laboratory of Microbiology and Biobank, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
Claudia Rotondo *Laboratory of Microbiology and Biobank, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
Luiz LadeiraBiomechanics Research Unit, GIGA Institute, University of Liège, Liège, Belgium.
Sara CrosettiLaboratory of Microbiology and Biobank, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
Michele ProperziLaboratory of Microbiology and Biobank, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
Valentina DimartinoLaboratory of Microbiology and Biobank, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
Benedetta RiccitelliLaboratory of Microbiology and Biobank, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
Bernard StaumontBiomechanics Research Unit, GIGA Institute, University of Liège, Liège, Belgium.
Giovanni ChillemiBioinformatics Research Unit in Infectious Diseases, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
Liesbet GerisBiomechanics Research Unit, GIGA Institute, University of Liège, Liège, Belgium.
Maria Grazia Bocci *Intensive Care Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.
Carla Fontana *Laboratory of Microbiology and Biobank, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Understanding host-pathogen interactions is crucial for explaining the variability in sepsis outcomes, with Methods: A scoping literature review enabled us to construct a domain-based infection network encompassing pathogenesis concepts, molecular interactions, and host response signatures, providing a wide view of the relevant mechanisms involved in severe bacterial infections. Results: Our analysis yielded a literature-based comprehensive description of Discussion: Our comprehensive molecular network of

Indexed as

bacterial infectiondisease maphost-pathogen interactionP. aeruginosasepsis

Identifiers

PMID41164165
PMCPMC12558848

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.