Evidence map›Paper›PMID 41164139›Full record

ArticleFrontiers in oncology2025

Interstitial pneumonia microenvironment promotes metastasis to the mediastinal lymph nodes and lungs.

Ryo Maeda, Mayu Inomata, Ryusei Yamada

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryo MaedaDepartment of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Mayu InomataDepartment of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Ryusei YamadaDepartment of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introductionhta: The prognosis of patients with lung cancer and interstitial lung disease (ILD) is worse than that of patients without ILDs; however, therapeutic options for ILD-associated lung cancer are severely limited. Although ILD is associated with an increased incidence of lung cancer, it is unclear whether the ILD lung environment affects the biological behavior of lung cancer. Methods: We tested our hypothesis that the lung environment of ILD is associated with the biological behavior and progression of lung cancer using an Results: The bleomycin-induced IP lung environment promoted metastasis to the mediastinal lymph nodes or contralateral lungs in an orthotopic model of lung cancer. The results of our Conclusion: We found that the IP lung environment promotes lung cancer metastasis. The results of this study may pave the way for further clinical studies on the use of PFD alone or in conjunction with conventional chemotherapy in patients with lung cancer and ILD.

Indexed as

fibroblastinterstitial lung diseaselung cancermetastasispirfenidone

Identifiers

PMID41164139
PMCPMC12558802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.