Evidence map›Paper›PMID 41164131›Full record

ArticleFrontiers in oncology2025

Case report: Von Hippel-Lindau syndrome with multisystem involvement: a therapeutic dilemma.

Shuai He, Cong Wang, Jing Yang, Juan Shen, Xiaozhu Zeng, Jun Zheng, Yongquan Wang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuai He *Department of Urology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Cong Wang *Department of Urology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Jing Yang *International Center for Aging and Cancer, Hainan Medical University, Haikou, Hainan, China.
Juan ShenDepartment of Urology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Xiaozhu ZengDepartment of Oncology, Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China.
Jun ZhengDepartment of Urology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.
Yongquan WangDepartment of Urology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a rare case of von Hippel-Lindau (VHL) syndrome type 2B, characterized by multisystem involvement including Stanford type B aortic dissection, pheochromocytoma, renal cell carcinoma (RCC), cerebellar hemangioblastoma with obstructive hydrocephalus, and extensive visceral cysts. This case highlights critical therapeutic dilemmas: urgent aortic repair versus risks of catecholamine surge from pheochromocytoma resection, and neurosurgical hazards of cerebellar lesions. We describe the diagnostic and therapeutic challenges associated with VHL syndrome, culminating in the development of a preliminary treatment strategy following multidisciplinary team (MDT) discussions. This study underscores the critical importance of early recognition and systematic MDT management to optimize clinical outcomes in VHL syndrome.

Indexed as

aortic dissectioncase reportearly recognitionmultidisciplinary managementvon Hippel-Lindau syndrome

Identifiers

PMID41164131
PMCPMC12558800

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.