Evidence map›Paper›PMID 41164087›Full record

ArticleBiomaterials research2025

Degradable Magnesium Implants with Caerin 1.9-Polycaprolactone Coatings Provide Extended Antibacterial Resistance and Outstanding Biocompatibility.

Xiaosong Liu, Guoying Ni, Guoqiang Chen, Xiaohong He, Pingping Zhang, Yuandong Luo, Quanlan Fu, Junjie Li, Shuxian Tang, Guowei Ni and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Caerin 1.1/1.9 peptides controlFrontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiaosong LiuCancer Research Institute, First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Guoying NiCancer Research Institute, First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Guoqiang ChenDepartment of Rheumatology, First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Xiaohong HeDepartment of Medical Imaging, First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Pingping ZhangCancer Research Institute, First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Yuandong LuoCancer Research Institute, First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Quanlan FuCancer Research Institute, First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Junjie LiThe First Affiliated Hospital, Clinical Medical School, Guangdong Pharmaceutical University, Guangzhou 510080, China.
Shuxian TangCancer Research Institute, First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Guowei NiSchool of Civil Architectural Engineering, North China University of Science and Technology, Tangshan 063000, China.
Zhengyi JiangSchool of Mechanical, Materials, Mechatronic and Biomedical Engineering, Faculty of Engineering and Information Sciences, University of Wollongong, Wollongong, NSW 2522, Australia.
Tsuyoshi FurushimaInstitute of Industrial Science, Department of Mechanical and Biofunctional Systems, the University of Tokyo, Meguro, Tokyo 153-8505, Japan.
Damon KentSchool of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore BC, QLD 4558, Australia.
Bin ZhuDepartment of Medical Imaging, First People's Hospital of Foshan, Foshan, Guangdong 528000, China.
Tianfang WangCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore BC, QLD 4558, Australia.
Hejie LiInstitute of Industrial Science, Department of Mechanical and Biofunctional Systems, the University of Tokyo, Meguro, Tokyo 153-8505, Japan.ORCID https://orcid.org/0000-0002-1135-5478

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-associated infections and foreign body responses remain major challenges in orthopedic and biomedical implant applications. In this study, we report a novel strategy to enhance the antibacterial and biocompatibility properties of magnesium (Mg) alloy implants by applying a biodegradable polycaprolactone (PCL) coating embedded with the host-defense peptide, caerin 1.9 (F3). Three Mg-based specimens, including pure Mg, cold-extruded AZ31, and fully annealed AZ31 (3A), were evaluated following PCL-F3 surface modification. The PCL-F3 coatings demonstrated sustained antibacterial efficacy both in vitro and in vivo, effectively inhibiting methicillin-resistant

Identifiers

PMID41164087
PMCPMC12559799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.