ArticleCureus2025
Obstructive Sleep Apnea as a Risk Factor for Pneumonia Among Patients Infected SARS-CoV-2: A Propensity Score-Matching Analysis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background Obstructive sleep apnea (OSA) and coronavirus disease 2019 (COVID-19) share key pathophysiological features, including intermittent hypoxemia, systemic inflammation, and endothelial dysfunction, which may worsen clinical outcomes. However, whether OSA independently increases the risk of COVID-19 pneumonia remains unclear. This study aimed to assess the association between OSA and the risk of COVID-19 pneumonia in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methodology In this single-center, cross-sectional study, 136 hospitalized patients with confirmed SARS-CoV-2 infection were evaluated. OSA was diagnosed using home sleep apnea testing (HSAT), defined by an apnea-hypopnea index (AHI)≥five events/hour. Propensity score matching (PSM) was performed at a 1:1 ratio based on age, sex, body mass index (BMI), smoking history, and hypertension. Multivariate logistic regression was used to identify independent risk factors for COVID-19 pneumonia. Results The overall prevalence of OSA among patients infected with SARS-CoV-2 was 36.76% (50/136). After PSM, 32 patients with OSA were matched to 32 controls without OSA. The prevalence of pneumonia-related abnormalities on chest computed tomography (CT), including patchy or ground-glass opacities, was significantly higher in the OSA group compared to the non-OSA group. Furthermore, patients with OSA exhibited more severe nocturnal hypoxemia, as reflected by elevated oxygen desaturation index (ODI) and increased total sleep time with oxygen saturation below 90% (TST90). Multivariate logistic regression analysis identified age ≥60 years (odds ratio (OR)=12.05,
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