ArticleFrontiers in microbiology2025
Archaea express circular isoforms of IS200/IS605-associated ωRNAs.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Circular RNAs (circRNAs) are RNA molecules with 5' and 3' ends covalently ligated. Their functions range from acting as genetic regulators to producing proteins, and they are often expressed in a tissue and condition-specific manner. Next-generation sequencing with prior RNA treatment with the RNase R exonuclease (circRNA-Seq) has been used to identify circRNAs in many organisms, especially in model eukaryotes. However, we know little about circRNAs in prokaryotes: they have not been consistently reported in bacteria and, to date, only a few circRNA-Seq studies have been done in archaea. We have developed a prokaryotic-specific computational pipeline, MonArch, that explores RNA-Seq reads for circRNA signatures. We annotated circRNAs in newly generated
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