Evidence map›Paper›PMID 41163986›Full record

ArticleNeurosurgery practice2025

Usefulness of Frameless Neuronavigation-Guided Stereotactic Biopsy for Brain Lesions Under Local Anesthesia: Surgical Outcomes and Feasibility for Molecular Diagnosis-Case Series.

Sho Osawa, Makoto Ohno, Yasuji Miyakita, Masamichi Takahashi, Shunsuke Yanagisawa, Mai Honda-Kitahara, Takuma Nakashima, Shohei Fujita, Takahiro Tsuchiya, Tetsufumi Sato and 5 more

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Article in Neurosurgery practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sho OsawaDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Makoto OhnoDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Yasuji MiyakitaDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Masamichi TakahashiDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Shunsuke YanagisawaDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Mai Honda-KitaharaDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
Takuma NakashimaDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
Shohei FujitaDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Takahiro TsuchiyaDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Tetsufumi SatoDepartment of Anesthesiology and Intensive Care Medicine, National Cancer Center Hospital, Tokyo, Japan.
Hirokazu SuginoDepartment of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
Akihiko YoshidaDepartment of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
Koichi IchimuraDepartment of Pathology, Kyorin University Faculty of Medicine, Mitaka, Japan.
Hiromichi SuzukiDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
Yoshitaka NaritaDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesFrameless neuronavigation-guided stereotactic biopsy (SB) is a common surgical technique for diagnosing intracranial lesions. A frameless SB is generally performed under general anesthesia; however, no reports are available on the efficacy and safety of frameless SBs under local anesthesia (LA). This study reports the surgical outcomes, diagnostic yield, and feasibility of molecular analyses after performing a frameless SB under LA (SB-LA).

methodsThe study retrospectively included patients who underwent a frameless SB-LA at our institute between March 2015 and January 2024. The clinical characteristics, intraoperative findings, completion rate of surgical procedure, complications, diagnostic yield, and feasibility of molecular analysis were analyzed retrospectively.

resultsThe study included 80 patients. Surgical procedures were completed in 79 patients (98.7%); the diagnosis was confirmed in 76 cases (95.0%). The diagnoses included diffuse gliomas (n = 38, 47.5%), primary central nervous system lymphomas (PCNSL; n = 27, 33.8%), other brain tumors (n = 4, 5.0%), demyelinating diseases (n = 2, 2.5%), and normal brain/gliosis (n = 5, 6.3%). All samples were sufficient for basic molecular analyses of isocitrate dehydrogenase

conclusionFrameless SB-LAs can be performed safely with a high diagnostic yield and feasibility for molecular analysis. Frameless SB-LAs improve early diagnoses and therapeutic interventions without compromising molecular information.

Indexed as

Case seriesLocal anesthesiaMolecular analysisNeuronavigationStereotactic brain biopsy

Identifiers

PMID41163986
PMCPMC12560739

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