ArticleNature and science of sleep2025
Association Between Obstructive Sleep Apnea and Prostate Cancer: NHANES and the Mendelian Randomization Study.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Obstructive sleep apnea is a common condition worldwide, and prostate cancer is the most prevalent cancer among men. However, the link between OSA and prostate cancer remains unclear. This study aims to explore the relationship between OSA and prostate cancer. Methods: Initially, a multivariable regression analysis was conducted to control for potential confounders and assess the impact of OSA on the risk of developing prostate cancer. Subsequently, age-stratified analyses were performed to further investigate the relationship between OSA and prostate cancer across different age groups. Finally, Mendelian randomization was employed to evaluate the causal relationship between OSA and prostate cancer risk. Results: The multivariable regression analysis of the NHANES data showed no significant association between OSA and prostate cancer after controlling for age, smoking habits, hypertension, diabetes, cardiovascular diseases, stroke, alcohol consumption, body mass index (OR = 0.83; 95% CI: 0.46-1.48; p = 0.49). However, age-stratified analysis revealed a significant negative correlation between OSA and prostate cancer in the younger population (<60 years) (OR = 0.07; 95% CI: 0.01-0.74; p = 0.03), whereas no significant association was found in the elderly population (≥60 years) (OR = 1.01; 95% CI: 0.69-1.49; p = 0.96). Finally, our Mendelian randomization results did not find a causal relationship between OSA and prostate cancer (OR = 0.992; 95% CI: 0.876-1.124; p = 0.906). Conclusion: The findings indicate that while there is no significant association between OSA and prostate cancer in the overall analysis, a significant negative correlation exists in the younger population. The lack of significant association in the Mendelian randomization analysis may be due to the inability to perform age stratification. Further prospective studies and mechanistic research are needed to better understand the biological mechanisms underlying this association.
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