ReviewPrecision radiation oncology2025
The evolution of prophylactic neck irradiation in nasopharyngeal carcinoma: Changing concepts and irradiation ranges.
Review in Precision radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Skeletal muscle status and malnutrition as predictors of short-term radiotherapy response and oral mucositis in head and neck cancer.Precision radiation oncology · 2026Article
- Fusion attention-based nasopharyngeal carcinoma segmentation model in predicting the clinical outcome of cervical lymph node residue after IMRT.BMC medical imaging · 2026Article
- Oral dryness related symptoms in radiation-treated head and neck cancer patients: a pilot study of oral microbiome composition and function.BMC microbiology · 2026Article
- Article
- Clinically deployable AI to predict objective response to radiotherapy-intensified immunotherapy in advanced hepatocellular carcinoma.Frontiers in oncology · 2026Article
- Interpretable AI for treatment decision-making in immunoradiotherapy of locally advanced nasopharyngeal carcinoma.Frontiers in oncology · 2026Article
- Artificial intelligence-based personalized treatment strategies for unresectable hepatocellular carcinoma: integrating HSP90α for prognosis and survival prediction.NPJ digital medicine · 2025Article
- The evolution of prophylactic neck irradiation in nasopharyngeal carcinoma: Changing concepts and irradiation ranges.Precision radiation oncology · 2025Review
- LASSO-Cox model in the prognostic evaluation of radiochemotherapy efficacy for lymph node metastatic nasopharyngeal carcinoma.Frontiers in oncology · 2025Article
- Prediction of prognosis in T4 or N3 locally advanced nasopharyngeal carcinoma receiving chemoradiotherapy using machine learning methods.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
The approach to prophylactic neck irradiation in nasopharyngeal carcinoma (NPC) has undergone significant changes. For decades, prophylactic whole-neck irradiation has been the standard for all patients with NPC; however, it is linked to a high risk of late complications. Advances in imaging modalities have deepened understanding of the metastatic characteristics of the cervical lymph nodes (LN), prompting a shift towards sparing the uninvolved lower neck and medial retropharyngeal nodal region. This targeted approach has proven effective in controlling cervical LN recurrence as whole-neck irradiation while significantly reducing adverse effects. Currently, contouring of the neck lymphatic drainage clinical target volume (CTV) is being explored to eliminate the use of uniform cervical LN levels as a delineation boundary. Instead, the inferior boundary of the neck CTV is determined either by the distance from the lowest positive LN or two cervical vertebrae below the lowest positive LN, facilitating more individualized CTV delineation and prophylactic neck irradiation. Additionally, omitting lower-risk neck lymphatic drainage CTVs and irradiating only visible LNs in these areas are also being explored. This review examines the evolution of prophylactic neck irradiation for NPC, providing key insights into these advancements.
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